Nitrilotriacetic acid
Based on 1 publication(s) in Google Scholar
Nitrilotriacetic acid is an orally active chelating agent for metal ions. Nitrilotriacetic acid is an aminotricarboxylic acid that can sequester metal ions as water soluble complexes. Nitrilotriacetic acid reacts with strong oxidizing agents such as hypochlorite, chlorine, ozone, or oxygen in the presence of palladium/carbon catalyst. Nitrilotriacetic acid interacts with solid phases such as cell membranes and bone matrices in the mammalian system. Nitrilotriacetic acid is classified as an epigenetic rodent carcinogen.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 139-13-9
- Formula: C6H9NO6
- Molecular Weight:191.14
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Nitrilotriacetic acid
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Biological Activity
Nitrilotriacetic acid (Compound NTA) (0-1250 μg/mL, 24 h) induces a statistically significant increase in the number of micronucleated cells on L5178Y mouse lymphoma cells without S9[1].
Nitrilotriacetic acid (625-2500 μg/mL, 24-44 h) induces a statistically significant increase in the number of micronuclei in both CTLL-2 and CTLL-2 bcl2 cells without S9, whilst not associated with an increase in the percentage of apoptotic cells[1].
Nitrilotriacetic acid (0-500 μg/mL, 24 h) significantly increases the NTA-induced mutation frequency[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 139-13-9
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Appearance Solid
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Molecular Weight 191.14
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Formula C6H9NO6
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Color White to off-white
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SMILES
O=C(CN(CC(O)=O)CC(O)=O)O
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Synonyms
Triglycollamic acid
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Microbiol
Functional and structural basis of human parainfluenza virus type 3 neutralization with human monoclonal antibodies. [Abstract]2024 Aug;9(8):2128-2143. PMID: 38858594
Solvent & Solubility
DMSO : 25 mg/mL (130.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
0.1 M NaOH : ≥ 19.11 mg/mL (99.98 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Nesslany, F., et al., (2008). Characterization of the genotoxicity of nitrilotriacetic acid. Environmental and molecular mutagenesis, 49(6), 439-452. [Content Brief]
[2]. Anderson RL, et al. A review of the environmental and mammalian toxicology of nitrilotriacetic acid. Crit Rev Toxicol. 1985;15(1):1-102. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 0.1 M NaOH / DMSO | 1 mM | 5.2318 mL | 26.1588 mL | 52.3177 mL | 130.7942 mL |
| 5 mM | 1.0464 mL | 5.2318 mL | 10.4635 mL | 26.1588 mL | |
| 10 mM | 0.5232 mL | 2.6159 mL | 5.2318 mL | 13.0794 mL | |
| 15 mM | 0.3488 mL | 1.7439 mL | 3.4878 mL | 8.7196 mL | |
| 20 mM | 0.2616 mL | 1.3079 mL | 2.6159 mL | 6.5397 mL | |
| 25 mM | 0.2093 mL | 1.0464 mL | 2.0927 mL | 5.2318 mL | |
| 30 mM | 0.1744 mL | 0.8720 mL | 1.7439 mL | 4.3598 mL | |
| 40 mM | 0.1308 mL | 0.6540 mL | 1.3079 mL | 3.2699 mL | |
| 50 mM | 0.1046 mL | 0.5232 mL | 1.0464 mL | 2.6159 mL | |
| 60 mM | 0.0872 mL | 0.4360 mL | 0.8720 mL | 2.1799 mL | |
| 80 mM | 0.0654 mL | 0.3270 mL | 0.6540 mL | 1.6349 mL | |
| DMSO | 100 mM | 0.0523 mL | 0.2616 mL | 0.5232 mL | 1.3079 mL |
Nitrilotriacetic acid Related Classifications
HY-W030778 Related Classifications
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