1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. 5-Hydroxydecanoate sodium

5-Hydroxydecanoate sodium 

Cat. No.: HY-136615
Handling Instructions

5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity.

For research use only. We do not sell to patients.

5-Hydroxydecanoate sodium Chemical Structure

5-Hydroxydecanoate sodium Chemical Structure

CAS No. : 71186-53-3

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Description

5-Hydroxydecanoate sodium is a selective ATP-sensitive K+ (KATP) channel blocker (IC50 of ~30 μM). 5-Hydroxydecanoate sodium is a substrate for mitochondrial outer membrane acyl-CoA synthetase and has antioxidant activity[1][2].

IC50 & Target

IC50: ~30 μM (KATP)

In Vitro

5-Hydroxydecanoate (5-HD) treatment abolishs the beneficial effects of penehyclidine hydrochloride (PHC) preconditioning in anoxia/reoxygenation (A/R)‐induced injury in H9c2 cells. 5-Hydroxydecanoate blocks the inhibitory effect of PHC on Ca2+ overload and ROS production. 5-Hydroxydecanoate promotes the release of Cyt-C from mitochondria into cytoplasm. 5-Hydroxydecanoate attenuats the anti-apoptotic effect of PHC. PHC treatment shows remarkably decreases levels of Bax and cleaved caspase-3, and increases levels of Bcl-2. 5-Hydroxydecanoate pretreatment reverses the effects of PHC on their expression levels. 5-Hydroxydecanoate blocks the effects of PHC on KATP channels[1].

In Vivo

5-Hydroxydecanoate (100 μM) treatment abolishes the effects of ischemic preconditioning (IPC) on the contractile recovery and does not affect its effect on the contracture, lactate production, glycogenolysis and viable tissue in rats[3].

Molecular Weight

210.25

Formula

C₁₀H₁₉NaO₃

CAS No.

71186-53-3

SMILES

CCCCCC(O)CCCC(O[Na])=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

5-HydroxydecanoatePotassium ChannelKcsAKATPROScytochrome cmitochondrialacyl-CoAischemicInhibitorinhibitorinhibit

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5-Hydroxydecanoate sodium
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