1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Almitrine mesylate

Almitrine mesylate (Synonyms: Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate)

Cat. No.: HY-107319 Purity: ≥99.0%
Handling Instructions

Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel.

For research use only. We do not sell to patients.

Almitrine mesylate Chemical Structure

Almitrine mesylate Chemical Structure

CAS No. : 29608-49-9

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Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Estimated Time of Arrival: December 31
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50 mg USD 120 In-stock
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100 mg USD 190 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel.

IC50 & Target

K+ channel[1]

In Vitro

Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+ channel by decreasing its open probability. The IC50 value of the effect is 0.22 μM. The inhibitory effect of Almitrine on Ca2+-dependent K+ channels also is observed in GH3 cells. Almitrine at concentrations up to 10 μM does not affect whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells. However, this concentration of Almitrine significantly inhibits the Ca2+-dependent component of K+ currents in rat chemoreceptor cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

669.76

Formula

C₂₈H₃₇F₂N₇O₆S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (149.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4931 mL 7.4654 mL 14.9307 mL
5 mM 0.2986 mL 1.4931 mL 2.9861 mL
10 mM 0.1493 mL 0.7465 mL 1.4931 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[2]

Rats[2]
8-week-old male spf Wistar rats are used. Rats are anaesthetized with Thiobarbiturate inactin (BYK, 100 mg/kg, i.p.). The interaction of the ventilatory response to hypoxia and an intermittent (2 min on, 1 min break) low-dose (10 μg/kg per min) and high-dose (80 μg/kg per min) infusion of S9581 or Almitrine is tested in control and chronically hypoxic rats. S9581 or Almitrine is infused intravenously (100 μg/ mL). Inspired oxygen levels were controlled by passing oxygen-nitrogen mixtures across the tracheal port at a flow rate of 3-41 min-1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product Name:
Almitrine mesylate
Cat. No.:
HY-107319
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