1. Protein Tyrosine Kinase/RTK
  2. RET
  3. BBT594

BBT594 (Synonyms: NVP-BBT594)

Cat. No.: HY-18840 Purity: 99.94%
Handling Instructions

BBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment.

For research use only. We do not sell to patients.

BBT594 Chemical Structure

BBT594 Chemical Structure

CAS No. : 882405-89-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
Estimated Time of Arrival: December 31
10 mg USD 190 In-stock
Estimated Time of Arrival: December 31
50 mg USD 490 In-stock
Estimated Time of Arrival: December 31
100 mg USD 750 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

BBT594 is a potent receptor tyrosine kinase RET inhibitor, used for cancer treatment.

In Vitro

NVP-BBT594 blocks the GDNF-mediated enhancement of MCF7-LTED cell viability in 2D culture and 3D colony formation. The addition of 10 pM E2, to mimic the E2 level in post-menopausal patients that have relapsed on AI treatment and ceased AI therapy, increases 3D colony formation of both MCF7 and MCF7-LTED cells, and this effect is efficiently reverted by NVP-BBT594. Parental T47D cells cultured in presence of low level E2, GFRα1/GDNF stimulation results in increased 3D colony formation, which is significantly reverted by NVP-BBT594. NVP-BBT594 targets GDNF-RET signaling and sensitizes MCF7-2A cells to letrozole treatment. NVP-BBT594 impairs GDNF-mediated RET downstream signaling and significantly enhances the antiproliferative effects of letrozole[1]. NVP-BBT594 shows the highest suppression of GDNF-induced RET signaling, as assessed by RET, ERK1/2, AKT and ER phosphorylation. NVP-AST487 and NVP-BBT594 have comparable RET inhibitory activity in wild-type MCF7 cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

569.58

Formula

C₂₈H₃₀F₃N₇O₃

CAS No.

882405-89-2

SMILES

O=C(N1CCC2=C1C=CC(OC3=NC=NC(NC(C)=O)=C3)=C2)NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (57.94 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7557 mL 8.7784 mL 17.5568 mL
5 mM 0.3511 mL 1.7557 mL 3.5114 mL
10 mM 0.1756 mL 0.8778 mL 1.7557 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.94%

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Keywords:

BBT594NVP-BBT594BBT 594BBT-594RETInhibitorinhibitorinhibit

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