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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
12 Results for "
Ceritinib
" in MedChemExpress (MCE) Product Catalog:
Products (12)
12 Results for "Ceritinib" in MCE Product Catalog:
43
43 Publications Verification
Synonyms: LDK378
Research Areas:
Ceritinib (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency .
43
43 Publications Verification
Synonyms: LDK378 dihydrochloride
Research Areas:
Ceritinib (LDK378) dihydrochloride is a selective, orally bioavailable and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib dihydrochloride shows great antitumor potency .
2
2 Cited Publications
Research Areas:
TL13-112 is a potent and selective ALK-PROTAC degrader and inhibits ALK activity with an IC50 value of 0.14 nM. TL13-112 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 8550 nM, 42.4 nM, 25.4 nM, and 677 nM, respectively. TL13-112 is comprised of the conjugation of Ceritinib (HY-15656) and the Cereblon ligand of Pomalidomide (HY-10984) .
Cat. No.: HY-179418
Ceritinib-platinum(IV)-4-phenylbutyrate (complex 7) is a Ceritinib (HY-15656)-conjugated Platinum(IV) prodrug with anticancer activity. Ceritinib-platinum(IV)-4-phenylbutyrate induces S-phase arrest, DNA damage responses, and apoptosis. Ceritinib-platinum(IV)-4-phenylbutyrate combines cytotoxicity with immune and anti-invasive activation in cancer cell models. Ceritinib-platinum(IV)-4-phenylbutyrate can be used for cancer research, such as non-small cell lung cancer (NSCLC) .
Cat. No.: HY-15656R
CAS No.: 1032900-25-6
Synonyms: LDK378 (Standard)
Research Areas:
Ceritinib (Standard) is the analytical standard of Ceritinib (HY-15656). This product is intended for research and analytical applications. Ceritinib is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency .
Synonyms: LDK378 d7
Cat. No.: HY-15656AR
CAS No.: 1380575-43-8
Synonyms: LDK378 dihydrochloride (Standard)
Research Areas:
Ceritinib (LDK378) dihydrochloride (Standard) is the analytical standard of Ceritinib dihydrochloride (HY-15656A). This product is intended for research and analytical applications. Ceritinib dihydrochloride is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib dihydrochloride also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib shows great antitumor potency .
Cat. No.: HY-120663
CAS No.: 1884321-89-4
Target:
Research Areas:
KRCA-0713 is an ALK inhibitor with anti-ALK activity. KRCA-0713 showed promising anti-ALK activity in enzyme and cell-based experiments. KRCA-0713 was shown to effectively inhibit ALK-driven tumor growth in H3122 xenograft model studies, similar to the effect of ceritinib .
Cat. No.: HY-I0875
CAS No.: 1260864-79-6
Target:
Research Areas:
Ceritinib impurity 5 is an impurity of Ceritinib (HY-15656).
Cat. No.: HY-180971
CAS No.: 2162120-74-1
Research Areas:
Ceritinib-amide-C3-acid is a target protein ligand-linker conjugate. Ceritinib-amide-C3-acid incorporates a protein ligand Ceritinib (HY-15656) and a link for E3 ligases ligand. Ceritinib-amide-C3-acid can be used for the synthesis of TD-004 (HY-180970) .
Cat. No.: HY-15656B
CAS No.: 2055376-74-2
Synonyms: LDK378 mesylate
Research Areas:
Ceritinib (LDK378) mesylate is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM. Ceritinib mesylate also inhibits IGF-1R, InsR, and STK22D with IC50 values of 8, 7, and 23 nM, respectively. Ceritinib mesylate shows great antitumor potency .
Cat. No.: HY-I0875R
CAS No.: 1260864-79-6
Target:
3-Methyl-4-(piperidin-4-yl)aniline (Standard) is the analytical standard of 3-Methyl-4-(piperidin-4-yl)aniline. This product is intended for research and analytical applications.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
