KRCA-0713
KRCA-0713 is an ALK inhibitor with anti-ALK activity. KRCA-0713 showed promising anti-ALK activity in enzyme and cell-based experiments. KRCA-0713 was shown to effectively inhibit ALK-driven tumor growth in H3122 xenograft model studies, similar to the effect of ceritinib.
For research use only. We do not sell to patients.
- CAS No.: 1884321-89-4
- Formula: C26H32ClN5O3S
- Molecular Weight:530.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | CC50 |
62 nM
Compound: 17b
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Inhibition of ALK L1196M mutant in mouse BA/F3 cells assessed as inhibition of cell proliferation after 72 hrs by WST1 assay
Inhibition of ALK L1196M mutant in mouse BA/F3 cells assessed as inhibition of cell proliferation after 72 hrs by WST1 assay
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[PMID: 26923695] |
Chemical Information
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CAS No. 1884321-89-4
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Molecular Weight 530.08
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Formula C26H32ClN5O3S
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SMILES
O=S(C1=C(NC2=NC(NC3=C(OC)C=C(C(C)(C(CC4)N)C)C4=C3)=NC=C2Cl)C=CC=C1)(C(C)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRCA-0713 Related Classifications
HY-120663 Related Classifications
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