1. GPCR/G Protein
  2. Adenylate Cyclase
  3. Cholera toxin

Cholera toxin (Synonyms: Choleragen)

Cat. No.: HY-P1446
Handling Instructions

Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER). Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein.

For research use only. We do not sell to patients.

Cholera toxin Chemical Structure

Cholera toxin Chemical Structure

CAS No. : 9012-63-9

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Description

Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER)[1]. Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein[2].

In Vitro

In the ER, a portion of Cholera toxin, the enzymatic A1-chain, is unfolded by protein disulfide isomerase and retro-translocated to the cytosol by hijacking components of the ER associated degradation pathway for misfolded proteins[1].
Cholera toxin acts as an ADP-ribosyltransferase to disrupt intracellular signaling in the target cell. Cholera toxin moves by vesicle carriers from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.

9012-63-9

SMILES

[Cholera toxin]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 10 mg/mL

*"≥" means soluble, but saturation unknown.

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Keywords:

Cholera toxinCholeragenAdenylate CyclaseAdenylyl cyclaseAB(5)-subunittoxingangliosideGM1misfoldedproteinsInhibitorinhibitorinhibit

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Cholera toxin
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