53179-11-6
Chemical Structure
Loperamide
Synonym(s): ADL 2-1294
- CAS No.: 53179-11-6
- Formula:C29H33ClN2O2
- Molecular Weight:477.04
InChIKey: RDOIQAHITMMDAJ-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)(CCN2CCC(C3=CC=C(C=C3)Cl)(CC2)O)C4=CC=CC=C4)N(C)C
Biological Activity: Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Loperamide | 99.85% | Loperamide (ADL 2-1294) is selective and orally active μ opioid receptor agonist with Ki valuess of 3, 48 and 1156 nM against μ, δ and κ opioid receptor, respectively. Loperamide produces antinociception and antihyperalgesia. Loperamide exhibits peripheral selectivity, enhancing fluid, electrolyte, and glucose absorption, reversing PGE2 (HY-101952)- and Cholera toxin (HY-P1446)-induced intestinal secretion, and reducing intestinal motility. Loperamide can be used for the researches of inflammatory pain and protracted diarrhoea. | ||||||||||||||||||||
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Loperamide-d6 | 98.88% | Loperamide-d6 is the deuterium labeled Loperamide. | ||||||||||||||||||||
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- [1]. DeHaven-Hudkins D L, et al. Loperamide (ADL 2-1294), an opioid antihyperalgesic agent with peripheral selectivity[J]. The Journal of pharmacology and experimental therapeutics, 1999, 289(1): 494-502.
- [2]. Sandhu BK, et al. Loperamide: studies on its mechanism of action. Gut. 1981;22(8):658-662. [Content Brief]
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