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  4. Etiracetam

Etiracetam is a racetam-class nootropic agent. Etiracetam enhances learning and memory in both normal and amnesic rats. Etiracetam can be used in studies related to memory retrieval disorders and amnesic diseases such as Alzheimer's disease.

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Etiracetam

Etiracetam Chemical Structure

CAS No. : 33996-58-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
50 mg In-stock
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200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Etiracetam Related Antibodies

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Description

Etiracetam is a racetam-class nootropic agent. Etiracetam enhances learning and memory in both normal and amnesic rats. Etiracetam can be used in studies related to memory retrieval disorders and amnesic diseases such as Alzheimer's disease[1][2].

IC50 & Target

Acetylcholine[1].
In Vivo

Etiracetam (25-500 mg/kg; i.p.; single administration 30 min before test / 10 days) does not alter spontaneous locomotor activity or the sensitivity of healthy male Wistar rats to inescapable foot shocks, enhances learning acquisition, and inhibits avoidance behavior[1].
Etiracetam (1-50 mg/kg; subcutaneous injection; single administration; administered 30 min before memory retention test) improves the passive avoidance performance of Wistar rats with amnesia induced by electroconvulsive shock (ECS)[2].
Etiracetam (50 mg/kg; subcutaneous injection; daily administration; administered 30 minutes prior to daily memory retention/relearning tests on days 2-5) significantly reduces the number of maze errors and running speed, as well as decreases the error count, in amnesic SD rats during the first memory retention test[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (WAG/Ry) (male, 2.5-3 months old, 150-170 g)[1]
Dosage: 25 mg/kg;100 mg/kg; 250 mg/kg; 500 mg/kg
Administration: i.p.; single dose/4, 10 days 30 min pre-test
Result: Exhibited no significant effect on measured spontaneous motor behavior parameters including distance run, entries into corner/inner field sections, time spent in inner field, movement speed, respiration rate, small/large movement counts, rearing count, or rearing time.
Did not alter flinch response thresholds to footshock.
Enhanced acquisition of the Y-maze discrimination task.
Significantly improved retention of the passive avoidance task in rats that received footshock.
Enhanced shuttlebox acquisition.
Inhibited extinction of the acquired avoidance behavior.
Animal Model: Wistar rats (male, 150-200 g)[2]
Dosage: 1 mg/kg; 10 mg/kg; 50 mg/kg
Administration: s.c.; single dose; 30 minutes pre-retention test
Result: Showed significantly better passive avoidance performance than saline-treated controls at 50 mg/kg.
Animal Model: Sprague-Dawley rats (male, 200-250 g at study start, maintained at 85% free-feeding weight via food deprivation)[2]
Dosage: 50 mg/kg
Administration: s.c.; daily; 2, 5 days, 30 minutes pre-retention/relearning trial each day
Result: Significantly reduced the number of errors on the first retention trial compared to saline-treated controls in good learners.
Significantly improved maze running speed and reduced errors
Molecular Weight

170.21

Formula

C8H14N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N)C(CC)N1C(CCC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (734.39 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8751 mL 29.3755 mL 58.7510 mL
5 mM 1.1750 mL 5.8751 mL 11.7502 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (12.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (12.22 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.88%

SDS (537 KB)

COA (252 KB) HNMR (243 KB) RP-HPLC (224 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8751 mL 29.3755 mL 58.7510 mL 146.8774 mL
5 mM 1.1750 mL 5.8751 mL 11.7502 mL 29.3755 mL
10 mM 0.5875 mL 2.9375 mL 5.8751 mL 14.6877 mL
15 mM 0.3917 mL 1.9584 mL 3.9167 mL 9.7918 mL
20 mM 0.2938 mL 1.4688 mL 2.9375 mL 7.3439 mL
25 mM 0.2350 mL 1.1750 mL 2.3500 mL 5.8751 mL
30 mM 0.1958 mL 0.9792 mL 1.9584 mL 4.8959 mL
40 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6719 mL
50 mM 0.1175 mL 0.5875 mL 1.1750 mL 2.9375 mL
60 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
80 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8360 mL
100 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
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Etiracetam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Etiracetam33996-58-6UCB 6474UCB6474UCB-6474Drug DerivativeDrug derivativenootropic agentAlzheimer's diseaseWistar ratsSprague-Dawley rats
Inhibitorinhibitorinhibit

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