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GSK2330672 (Synonyms: linerixibat)

Cat. No.: HY-16643 Purity: 99.55%
Handling Instructions

GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) which lowers glucose in an animal model of type 2 diabetes and shows excellent developability properties for evaluating the potential therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes.

For research use only. We do not sell to patients.

GSK2330672 Chemical Structure

GSK2330672 Chemical Structure

CAS No. : 1345982-69-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 433 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Stock in the United States
Estimated Time of Arrival: December 31
5 mg USD 360 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

GSK2330672 is a highly potent, nonabsorbable ASBT(apical sodium-dependent bile acid transporter) inhibitor (hASBT IC50=42 ± 3 nM) which lowers glucose in an animal model of type 2 diabetes and shows excellent developability properties for evaluating the potential therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes. IC50 value: 42 ± 3 nM [1] Target: hASBT in vitro: GSK2330672 is a highly potent, nonabsorbable ASBT inhibitor with excellent aqueous solubility, selectivity, and developability properties for evaluation in safety studies and ultimately humans. GSK2330672 will be a valuable clinical tool for exploring the therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes.[1] in vivo: GSK2330672 results in potent inhibition of ASBT and very low oral absorption in the rat. GSK2330672 shows potent mouse and rat ASBT activity and was stable in GI stability assays. GSK2330672 is stable in the rodent GI tract and potently induced fecal bile acid excretion in mice, leading us to select these three compounds for mechanistic and efficacy studies in vivo in lean rats and Zucker Diabetic Fatty (ZDF) rats, respectively.[1]

Clinical Trial
References
Molecular Weight

546.68

Formula

C₂₈H₃₈N₂O₇S

CAS No.

1345982-69-5

SMILES

O=C(O)CC(NCC1=C(OC)C=C(C2=C1)[[email protected]@H](C3=CC=CC=C3)N[[email protected]](CC)(CCCC)CS2(=O)=O)CC(O)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 21.5 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.55%

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Product Name:
GSK2330672
Cat. No.:
HY-16643
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