1. Metabolic Enzyme/Protease
    NF-κB
  2. MALT1
  3. MLT-748

MLT-748 

Cat. No.: HY-115466 Purity: 99.91%
Handling Instructions

MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM.

For research use only. We do not sell to patients.

MLT-748 Chemical Structure

MLT-748 Chemical Structure

CAS No. : 1832578-30-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

MLT-748 is a potent, selective and allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM[1].

IC50 & Target

IC50: 5 nM (MALT1)[1]
Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728))[1]

In Vitro

MLT-748 reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].
MLT-748 (0-2 μM) stabilizes cellular MALT1-W580S, with an EC50 of 69 nM[1].
MLT-748 (2 µM, 24 hours) increases the phosphorylation of p65 and IκBα in MALT1mut/mut patient immortalized B cells[1].

Western Blot Analysis

Cell Line: MALT1mut/mut patient immortalized B cells
Concentration: 2 µM
Incubation Time: 24 hours
Result: Increased NF-κB signaling phosphorylation of both p65 and IκBα as early as 5 min after stimulation with PMA and ionomycin.
Molecular Weight

492.32

Formula

C₁₉H₁₉Cl₂N₉O₃

CAS No.

1832578-30-9

SMILES

O=C(NC1=CC(Cl)=C(N2N=CC=N2)N=C1)NC3=C([[email protected]@H](OC)[[email protected]](OC)C)N4C(N=C3)=CC(Cl)=N4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 250 mg/mL (507.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0312 mL 10.1560 mL 20.3120 mL
5 mM 0.4062 mL 2.0312 mL 4.0624 mL
10 mM 0.2031 mL 1.0156 mL 2.0312 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.22 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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MLT-748
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HY-115466
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