1. Anti-infection
  2. Enterovirus
  3. Pocapavir

Pocapavir (Synonyms: SCH-48973; V-073)

Cat. No.: HY-104074 Purity: 99.14%
Handling Instructions

Pocapavir (SCH-48973;V-073), a capsid inhibitor, preventing virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections.

For research use only. We do not sell to patients.

Pocapavir Chemical Structure

Pocapavir Chemical Structure

CAS No. : 146949-21-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 119 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 288 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Pocapavir (SCH-48973;V-073), a capsid inhibitor, preventing virion uncoating upon entry into the cell. Pocapavir has antiviral activity against polioviruses. Pocapavir also inhibits enterovirus infections[1].

In Vitro

Pocapavir acts as a capsid inhibitor, preventing virion uncoating upon entry into the cell. Treatment with Pocapavir is safe and significantly accelerates virus clearance[1]. Pocapavir, an investigational oral antiviral, has been used in a case of neonatal enterovirus sepsis. Pocapavir, also known as SCH 48973 and V-073, is a potent, selective anti-enteroviral agent only available as an emergency investigational drug. Pocapavir belongs to a picornavirus antiviral mechanistic class called capsid inhibitors that block virus uncoating and viral RNA release into cells, which in turn prevents virus replication[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

423.72

Formula

C₂₁H₁₇Cl₃O₃

CAS No.

146949-21-5

SMILES

ClC1=C(OCC2=CC=C(COC3=CC=C(OC)C=C3Cl)C=C2)C(Cl)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (236.00 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3600 mL 11.8002 mL 23.6005 mL
5 mM 0.4720 mL 2.3600 mL 4.7201 mL
10 mM 0.2360 mL 1.1800 mL 2.3600 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.14%

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Keywords:

PocapavirSCH-48973 V-073SCH48973SCH 48973V073V 073V-073EnterovirusRhinovirusHRVHRVsHEVHEVspolioendgamepoliovirusesInhibitorinhibitorinhibit

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Pocapavir
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