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RO8994

HY-16999

(RO-8994)

RO8994

RO8994 Chemical Structure

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).

Size Price Stock Quantity
10 mM * 1 mL in DMSO $472 In-stock
5 mg $350 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg Get quote
500 mg Get quote
Size Price Stock Quantity
10 mM * 1 mL in DMSO €463 In-stock
5 mg €343 In-stock
10 mg €490 In-stock
50 mg €1470 In-stock
100 mg €2058 In-stock
200 mg Get quote
500 mg Get quote

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Product name: RO8994
Cat. No.: HY-16999

RO8994 Data Sheet

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    Purity: 99.38%%

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    DataSheet

    Pdf Version

    COA

Related Compound Libraries

Biological Activity of RO8994

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays).
IC50 value: 5 nM (in HTRF binding assays), 20 nM (in MTT proliferation assays)
Target: MDM2
in vitro: RO8994 represents a new generation of p53-MDM2 antagonists with marked improvement in pharmacological properties for potential clinical development. RO8994 induces dose-dependent up-regulation of p53 target genes and apoptosis in wild-type p53 cancer cells, consistent with its non-genotoxic mechanism of p53 activation.
in vivo: RO8994 displays remarkable tumor growth inhibition in the wild-type p53, MDM2-amplified SJSA-1 osteosarcoma tumor xenograft model - exhibiting significant (>60%) tumor growth inhibition at the low dose of 1.56 mg/kg, tumor stasis at 3.125 mg/kg and regression at 6.25 mg/kg.

Protocol (Extracted from published papers and Only for reference)

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Chemical Information

M.Wt 613.51 Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Formula C31H31Cl2FN4O4
CAS No 1309684-94-3
Solvent & Solubility

DMSO:45mg/mL

Preparing Stock Solutions

1 mg 5 mg 10 mg
1 mM 1.6300 mL 8.1498 mL 16.2997 mL
5 mM 0.3260 mL 1.6300 mL 3.2599 mL
10 mM 0.1630 mL 0.8150 mL 1.6300 mL

References on RO8994

Inhibitor Kit

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