1. GPCR/G Protein
  2. Oxytocin Receptor
  3. Retosiban

Retosiban (Synonyms: GSK 221149; GSK 221149A)

Cat. No.: HY-14778 Purity: 98.97%
Handling Instructions

Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.

For research use only. We do not sell to patients.

Retosiban Chemical Structure

Retosiban Chemical Structure

CAS No. : 820957-38-8

Size Price Stock Quantity
5 mg USD 680 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3500 Get quote
100 mg USD 5500 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Retosiban (GSK221149A) is a potent and selective oxytocin antagonist with a Ki of 0.65 nM.

IC50 & Target

IC50: 0.65 nM (Oxytocin)[1]

Clinical Trial
Molecular Weight

494.58

Formula

C₂₇H₃₄N₄O₅

CAS No.

820957-38-8

SMILES

O=C([[email protected]@H](C1CC2=C(C=CC=C2)C1)N3)N([[email protected]](C4=COC(C)=N4)C(N5CCOCC5)=O)[[email protected]]([[email protected]](CC)C)C3=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (202.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0219 mL 10.1096 mL 20.2192 mL
5 mM 0.4044 mL 2.0219 mL 4.0438 mL
10 mM 0.2022 mL 1.0110 mL 2.0219 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RetosibanGSK 221149 GSK 221149AGSK221149GSK-221149Oxytocin ReceptorOXTRInhibitorinhibitorinhibit

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Product Name:
Retosiban
Cat. No.:
HY-14778
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