ICMT
Isoprenylcysteine carboxyl methyltransferase
ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].
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ICMT 관련 제품 (67)
관련 제품 (67)
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ICMT-IN-20
0 ImagesCat. No.: HY-155427CAS No.: 1313603-01-8ICMT-IN-20 (compound 54) is an inhibitor of ICMT (IC50=0.682 μM).
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ICMT-IN-44
0 ImagesCat. No.: HY-157112CAS No.: 1313602-69-5ICMT-IN-44 (compound 23) is an inhibitor of ICMT (IC50=0.167 μM).
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(R)-ICMT-IN-3
0 ImagesCat. No.: HY-157092B(R)-ICMT-IN-3 (compound ent 2-27) is an inhibitor of ICMT (IC50=0.01 μM).
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ICMT-IN-36
0 ImagesCat. No.: HY-157104CAS No.: 1313602-86-6ICMT-IN-36 (compound 40) is an inhibitor of ICMT (IC50=0.181 μM).
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ICMT-IN-12
0 ImagesCat. No.: HY-149706CAS No.: 1313603-25-6ICMT-IN-12 (compound 78) is an inhibitor of ICMT (IC50=0.42 μM).
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ICMT-IN-8
0 ImagesCat. No.: HY-157096CAS No.: 1313602-76-4ICMT-IN-8 (compound 30) is an inhibitor of ICMT (IC50=0.652 μM).
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ICMT-IN-17
0 ImagesCat. No.: HY-155425CAS No.: 1313602-99-1ICMT-IN-17 (compound 52) is an inhibitor of ICMT (IC50=0.38 μM).
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ICMT-IN-26
0 ImagesCat. No.: HY-157102CAS No.: 1313602-84-4ICMT-IN-26 (compound 38) is an inhibitor of ICMT (IC50=0.36 μM).
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ICMT-IN-16
0 ImagesCat. No.: HY-157098CAS No.: 1313602-79-7ICMT-IN-16 (compound 33) is an inhibitor of ICMT (IC50=0.131 μM).
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ICMT-IN-41
0 ImagesCat. No.: HY-157109CAS No.: 1313602-66-2ICMT-IN-41 (compound 20) is an inhibitor of ICMT (IC50=0.069 μM).
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ICMT-IN-31
0 ImagesCat. No.: HY-155434CAS No.: 1313603-15-4ICMT-IN-31 (compound 68) is an inhibitor of ICMT (IC50=0.0038 μM).
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ICMT-IN-54
0 ImagesCat. No.: HY-149730CAS No.: 908856-14-4ICMT-IN-54 (compound 7c) is an adamantyl analogue and an ICMT inhibitor (IC50=12.4 μM), which can inhibit ICMT Methylation. ICMT-in-54 inhibits BFC (N-biotinyl-(6-aminohexanoic)-S-farnesyl-L-cysteine) methylation in saccharomyces cerevisiae expressing ICMT, which is an indirect effect of inhibiting ICMT methylation.
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ICMT-IN-18
0 ImagesCat. No.: HY-157099CAS No.: 1313602-81-1ICMT-IN-18 (compound 35) is an inhibitor of ICMT (IC50=0.066 μM).
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ICMT-IN-40
0 ImagesCat. No.: HY-157108CAS No.: 1313602-65-1ICMT-IN-40 (compound 19) is an inhibitor of ICMT (IC50=0.031 μM).
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ICMT-IN-11
0 ImagesCat. No.: HY-155421CAS No.: 1313602-94-6ICMT-IN-11 (compound 48) is an inhibitor of ICMT (IC50=0.031 μM).
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ICMT-IN-29
0 ImagesCat. No.: HY-155432CAS No.: 1313603-13-2ICMT-IN-29 (compound 66) is an inhibitor of ICMT (IC50=0.019 μM).
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ICMT-IN-38
0 ImagesCat. No.: HY-157106CAS No.: 1313602-88-8ICMT-IN-38 (compound 42) is an inhibitor of ICMT (IC50=0.049 μM).
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ICMT-IN-43
0 ImagesCat. No.: HY-157111CAS No.: 1313602-68-4ICMT-IN-43 (compound 22) is an inhibitor of ICMT (IC50=0.04 μM).
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ICMT-IN-39
0 ImagesCat. No.: HY-157107CAS No.: 1313602-64-0ICMT-IN-39 (compound 18) is an inhibitor of ICMT (IC50=0.031 μM).
