ICMT
Isoprenylcysteine carboxyl methyltransferase
ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].
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ICMT Related Products (67)
Related Products (67)
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ICMT-IN-55
0 ImagesCat. No.: HY-157206CAS No.: 1313602-77-5ICMT-IN-55 (compound 31) is an ICMT inhibitor with IC50=90 nM.
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Spermatinamine
0 ImagesCat. No.: HY-149712CAS No.: 1001438-81-8Spermatinamine is a novel alkaloid with a bromotyrosyl-spermine-bromotyrosyl sequence, and a natural ICMT inhibitor. Spermatinamine can be isolated from the Australian sponge Pseudoceratina.
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CAY10677
0 ImagesCat. No.: HY-117776CAS No.: 1443253-20-0CAY10677 (compound 15) is a potent ICMT inhibitor that inhibits cancer cell proliferation. CAY10677 has good PAMPA penetration.
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J1-1
0 ImagesCat. No.: HY-149713CAS No.: 1244769-10-5J1-1 is an inhibitor of ICMT with an IC50 of 1.0 μM and has anticancer activity.
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POP-3MB
0 ImagesCat. No.: HY-149710CAS No.: 1144114-27-1POP-3MB (compound 1b) is an ICMT inhibitor (IC50: 2.5 μM). POP-3MB changes the subcellular localization of K-Ras and inhibits Ras activation. POP-3MB also inhibits Erk phosphorylation.
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J6-3
0 ImagesCat. No.: HY-149714J6-3 is an inhibitor of ICMT with an IC50 of 0.6 μM and has anticancer activity. J6-3 inhibits MDA-MB231 cells with an IC50 of 3.4 μM.
