ICMT
Isoprenylcysteine carboxyl methyltransferase
ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].
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ICMT Related Products (67)
Related Products (67)
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ICMT-IN-32
0 ImagesCat. No.: HY-155435CAS No.: 1313603-17-6ICMT-IN-32 (compound 70) is an inhibitor of ICMT (IC50=0.777 μM).
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ICMT-IN-23
0 ImagesCat. No.: HY-157100CAS No.: 1313602-82-2ICMT-IN-23 (compound 36) is an inhibitor of ICMT (IC50=0.123 μM).
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ICMT-IN-10
0 ImagesCat. No.: HY-157097CAS No.: 1313602-78-6ICMT-IN-10 (compound 32) is an inhibitor of ICMT (IC50=0.184 μM).
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ICMT-IN-25
0 ImagesCat. No.: HY-157101CAS No.: 1313602-83-3ICMT-IN-25 (compound 37) is an inhibitor of ICMT (IC50=0.025 μM).
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ICMT-IN-53
0 ImagesCat. No.: HY-149729CAS No.: 1443253-17-5ICMT-IN-53 (compound 12) is an ICMT inhibitor (IC50=0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC50s of 5.14 μM and 5.88 μM, respectively.
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ICMT-IN-48
0 ImagesCat. No.: HY-157116CAS No.: 337486-54-1ICMT-IN-48 (compound 1) is an ICMT inhibitor that is competitive (Km=13 μM) for the prenylated methyl acceptor, the first substrate of ICMT. ICMT-IN-48 inhibits ICMT activity with IC50s affected by the concentration of the second substrate S-adenosylmethinine (SAM), and the IC50s are 3.5 μM (1×Km SAM) and 2.3 μM (10×Km SAM), respectively.
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ICMT-IN-45
0 ImagesCat. No.: HY-157113CAS No.: 1313602-70-8ICMT-IN-45 (compound 24) is an inhibitor of ICMT (IC50=0.132 μM).
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ICMT-IN-2
0 ImagesCat. No.: HY-155418CAS No.: 1313602-91-3ICMT-IN-2 (compound 45) is an inhibitor of ICMT (IC50=0.168 μM).
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ICMT-IN-14
0 ImagesCat. No.: HY-155423CAS No.: 1313602-97-9ICMT-IN-14 (compound 50) is an inhibitor of ICMT (IC50=0.025 μM).
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ICMT-IN-47
0 ImagesCat. No.: HY-157115CAS No.: 1313602-72-0ICMT-IN-47 (compound 26) is an inhibitor of ICMT (IC50=0.76 μM).
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ICMT-IN-19
0 ImagesCat. No.: HY-155426CAS No.: 1313603-00-7ICMT-IN-19 (compound 53) is an inhibitor of ICMT (IC50=0.026 μM).
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ICMT-IN-22
0 ImagesCat. No.: HY-155428CAS No.: 1313603-09-6ICMT-IN-22 (compound 62) is an inhibitor of ICMT (IC50=0.63 μM).
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ICMT-IN-49
0 ImagesCat. No.: HY-157117CAS No.: 303728-92-9ICMT-IN-49 (compound 2) is an inhibitor of ICMT (IC50=0.12 μM).
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ICMT-IN-42
0 ImagesCat. No.: HY-157110CAS No.: 1313602-67-3ICMT-IN-42 (compound 21) is an inhibitor of ICMT (IC50=0.054 μM).
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ICMT-IN-9
0 ImagesCat. No.: HY-155420CAS No.: 1313602-93-5ICMT-IN-9 (compound 47) is an inhibitor of ICMT (IC50=0.16 μM).
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ICMT-IN-3
0 ImagesCat. No.: HY-157092CAS No.: 1313602-73-1ICMT-IN-3 (compound 27) is an inhibitor of ICMT (IC50=0.015 μM).
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ICMT-IN-4
0 ImagesCat. No.: HY-157094CAS No.: 1313602-74-2ICMT-IN-4 (compound 28) is an inhibitor of ICMT (IC50=0.27 μM).
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ICMT-IN-35
0 ImagesCat. No.: HY-149709ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 μM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 μM) against metastatic pancreatic cancer cell lines.
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ICMT-IN-33
0 ImagesCat. No.: HY-155436CAS No.: 1313603-20-1ICMT-IN-33 (compound 73) is an inhibitor of ICMT (IC50=0.46 μM).
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R1-11
0 ImagesCat. No.: HY-149715R1-11 is an indole ICMT inhibitor with an IC50 of 0.6 μM and has anticancer activity. R1-11 inhibits MDA-MB231 and PC3 cells with IC50s of 2.2 μM and 2.0 μM, respectively.
