1. Antibody-drug Conjugate/ADC Related
    Cell Cycle/DNA Damage
    Cytoskeleton
  2. Drug-Linker Conjugates for ADC
    Microtubule/Tubulin

Vc-MMAD 

Cat. No.: HY-15742
Handling Instructions

Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.

For research use only. We do not sell to patients.
Vc-MMAD Chemical Structure

Vc-MMAD Chemical Structure

CAS No. : 1401963-17-4

Size Price Stock Quantity
10 mM * 1 mL in DMSO $2147 In-stock
1 mg $550 In-stock
5 mg $930 In-stock
10 mg $1425 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate. IC50 Valu: N/A Target: tubulin; ADCs Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate. For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 0.7301 mL 3.6504 mL 7.3008 mL
5 mM 0.1460 mL 0.7301 mL 1.4602 mL
10 mM 0.0730 mL 0.3650 mL 0.7301 mL
References
M.Wt

1369.71

Formula

C₇₀H₁₀₄N₁₂O₁₄S

CAS No.

1401963-17-4

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Vc-MMAD
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HY-15742
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