2. Metabolic Enzyme/Protease
  3. Xanthine Oxidase
  4. AA 193

AA 193 is an orally active uricosuric agent. AA 193 inhibits the net reabsorption of uric acid in nephrons, regulates the renal reabsorption process of filtered uric acid, promotes uric acid excretion in a dose-dependent manner, and reduces serum uric acid levels. AA 193 mildly inhibits the activity of xanthine dehydrogenase (XDH). AA 193 can be used in studies related to hyperuricemia.

For research use only. We do not sell to patients.

AA 193

AA 193 Chemical Structure

CAS No. : 107804-48-8

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

AA 193 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AA 193 is an orally active uricosuric agent. AA 193 inhibits the net reabsorption of uric acid in nephrons, regulates the renal reabsorption process of filtered uric acid, promotes uric acid excretion in a dose-dependent manner, and reduces serum uric acid levels. AA 193 mildly inhibits the activity of xanthine dehydrogenase (XDH). AA 193 can be used in studies related to hyperuricemia[1][2].

In Vitro

AA 193 (1 mM; 20 min) has no effect on uricase activity in the lysosomal fraction of rat liver homogenate[1].
AA 193 (0.2-1 mM; 20 min) shows no effect on xanthine dehydrogenase activity in the cytosolic fraction of rat liver homogenate at a concentration of 0.2 mM, while 1 mM AA-193 slightly inhibits the activity of this enzyme[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AA 193 Related Antibodies
In Vivo

AA-193 (20-100 mg/kg; p.o.; once daily; for 7 consecutive days) maintains dose-dependent uricosuric activity without altering plasma uric acid levels after 7 consecutive days of daily oral administration in normal rats[1].
AA-193 (20-100 mg/kg; p.o.; once daily; for 7 consecutive days) exerts dose-dependent urate-lowering activity in hyperuricemic rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar-Immamichi (8-week-old male, normal, fed standard diet pellet CE-2)[1]
Dosage: 20 mg/kg; 50 mg/kg; 100 mg/kg
Administration: p.o.; daily; 7 days
Result: Increased 24-hour urate excretion by 16.9% (20 mg/kg), 24.4% (50 mg/kg), and 25.0% (100 mg/kg) compared to vehicle control after first administration.
Maintained dose-dependent uricosuric activity over 7 consecutive administrations.
Did not significantly alter plasma urate concentrations throughout the study.
Increased plasma allantoin by 11.4% in the 100 mg/kg group on day 7, while urinary and plasma allantoin levels were largely unchanged otherwise.
Increased fractional excretion of urate at 50 mg/kg, with peak responses occurring 2 hours after administration, correlating with plasma AA-193 concentrations (57.1 μg/mL at 2 hours, 21.1 μg/mL at 8 hours on day 1, undetectable by 24 hours).
Showed similar plasma AA-193 concentration time course on day 1 and day 7.
Animal Model: Wistar-Immamichi (8-week-old male, hyperuricemic, fed standard diet pellet CE-2 blended with 2.5% oxonate potassium salt for days 1 to 8)[1]
Dosage: 20 mg/kg; 50 mg/kg; 100 mg/kg
Administration: p.o.; daily; 7 days
Result: Increased urate excretion rate at all doses.
Caused a dose-dependent decrease in plasma urate levels, with a significant 18.2% reduction in the 100 mg/kg group on day 7 compared to vehicle control.
Left plasma and urinary allantoin levels unchanged.
Increased fractional excretion of urate at 50 mg/kg, mirroring the relationship seen in normal rats.
Resulted in plasma urate levels and urate excretion rates 6 to 10 times higher than in normal rats, while fractional excretion of urate and inulin clearance values were comparable to normal rats.
Molecular Weight

315.71

Formula

C16H10ClNO4
CAS No.
SMILES

O=C(C1OC2=C(C1)C3=C(C(C4=CC=CC=C4)=NO3)C=C2Cl)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AA 193 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AA 193107804-48-8AA193AA-193Xanthine OxidaseXOnephronrenal reabsorptionxanthine dehydrogenasemiceuricaseWistar-Immamichi ratcebus monkeyshyperuricemiauric acidurateInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AA 193
Cat. No.:
HY-106300
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.