2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK) Insulin Receptor
  4. ALK-IN-24

ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. ALK-IN-24 also inhibits insulin receptor kinase with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells. ALK-IN-24 inhibits ALK-driven tumor growth in xenograft mouse models. ALK-IN-24 can be used in research related to non-small cell lung cancer.

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ALK-IN-24

ALK-IN-24 Chemical Structure

CAS No. : 2093414-37-8

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ALK-IN-24 Related Antibodies

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Description

ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. ALK-IN-24 also inhibits insulin receptor kinase with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells. ALK-IN-24 inhibits ALK-driven tumor growth in xenograft mouse models. ALK-IN-24 can be used in research related to non-small cell lung cancer[1].

Cellular Effect
Cell Line Type Value Description References
NCI-H3122 TGI
86.3 %
Compound: 29
Antitumor activity against human NCI-H3122 cells xenografted in BALB/c nu/nu mouse assessed as tumor growth inhibition at 50 mg/kg administered once daily via oral gavage for 14 days measured twice weekly during compound dosing relative to control
Antitumor activity against human NCI-H3122 cells xenografted in BALB/c nu/nu mouse assessed as tumor growth inhibition at 50 mg/kg administered once daily via oral gavage for 14 days measured twice weekly during compound dosing relative to control
[PMID: 28385505]
In Vitro

ALK-IN-24 (Compound 6) inhibits wild-type ALK and ALKL1196M mutant kinases in the HTRF KinEASE-TK enzymatic assay, with IC50 values of 1.7 nM and 8.1 nM, respectively[1].
ALK-IN-24 inhibits insulin receptor kinase with an IC50 of 6.0 nM in the HTRF KinEASE-TK enzymatic activity assay[1].
ALK-IN-24 inhibits the proliferation of H3122 cells in cell-based proliferation assays, with a CC50 of 36 nM[1].
ALK-IN-24 inhibits the proliferation of BaF3 cells expressing ALKL1196M in cell-based proliferation assays, with a CC50 of 120 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALK-IN-24 Related Antibodies
In Vivo

ALK-IN-24 (50 mg/kg; p.o.; once daily; for 14 consecutive days) achieves a tumor growth inhibition rate of 86.3% in SCID mice bearing H3122 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (8 mice per group)[1]
Dosage: 50 mg/kg
Administration: p.o.; daily; 14 days
Result: Achieved a tumor growth inhibition (TGI) rate of 86.3% during the 14-day treatment period.
Showed slow tumor regrowth after treatment discontinuation.
Caused no changes in body weight or side effects during the study.
Molecular Weight

556.08

Formula

C26H30ClN7O3S
CAS No.
SMILES

O=S(=O)(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC=3C=C4C(=CC3OC)N5C(=NN(C)CC5)CC4)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ALK-IN-24 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK-IN-242093414-37-8Anaplastic lymphoma kinase (ALK)Insulin ReceptorAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246ALK inhibitornon-small cell lung cancerH3122 cellsSCID mice
Inhibitorinhibitorinhibit

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