2093414-37-8
Chemical Structure
ALK-IN-24
- CAS No.: 2093414-37-8
- Formula:C26H30ClN7O3S
- Molecular Weight:556.08
IUPAC Name: 5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(9-methoxy-3-methyl-2,3,5,6-tetrahydro-1H-[1,2,4]triazino[4,3-a]quinolin-8-yl)pyrimidine-2,4-diamine
InChIKey: CKZWESXBMQBAAD-UHFFFAOYSA-N
SMILES: O=S(=O)(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC=3C=C4C(=CC3OC)N5C(=NN(C)CC5)CC4)C(C)C
Biological Activity: ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. ALK-IN-24 also inhibits insulin receptor kinase with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells. ALK-IN-24 inhibits ALK-driven tumor growth in xenograft mouse models. ALK-IN-24 can be used in research related to non-small cell lung cancer[1].
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ALK-IN-24 | ALK-IN-24 is an orally active ALK inhibitor with an IC50 value of 1.7 nM. ALK-IN-24 also inhibits insulin receptor kinase with an IC50 value of 6 nM. ALK-IN-24 suppresses the proliferation of lung adenocarcinoma cells. ALK-IN-24 inhibits ALK-driven tumor growth in xenograft mouse models. ALK-IN-24 can be used in research related to non-small cell lung cancer. | |||||||||||||||||||||
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Keywords
