OBFC2B Antibody (YA8550)
(Synonyms: hSSB1; OBFC2B; SOSS-B1; SSB1)OBFC2B Antibody (YA8550) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OBFC2B.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100 |
Product Details
OBFC2B Antibody (YA8550) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to OBFC2B.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 22.2 kDa
Full length human recombinant protein of human OBFC2B produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
OBFC2B component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways[1].
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
Q9BQ15 has two isomers: Q9BQ15-1: 22338 Da (predicted); Q9BQ15-2: 11493 Da (predicted).
Phosphorylated by ATM in response to DNA damage丨Ubiquitinated in a FBXL5-dependent manner, leading to proteasomal degradation -
Subunit
Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP
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SwissProt ID
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Synonyms
hSSB1; OBFC2B; SOSS-B1; SSB1
Documentation
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