ZBED1 (DREF) Antibody (YA8557)
(Synonyms: ALTE; DREF; hDREF; TRAMP)ZBED1 (DREF) Antibody (YA8557) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ZBED1 (DREF).
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100 |
Product Details
ZBED1 (DREF) Antibody (YA8557) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to ZBED1 (DREF).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 78 kDa
Full length human recombinant protein of human ZBED1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ZBED1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins |(Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection[1][2][3][4].
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Subcellular Localization
Nucleus, PML body,Nucleus,Nucleus, PML body
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Expression
Tissue_Specificity: Ubiquitously expressed at low levels (PubMed:9887332). Expression is highest in skeletal muscle, heart, spleen and placenta (PubMed:9887332)
Induction: Expression is linked to the cell cycle: low in serum-starved fibroblasts, increasing during the G1/S phase, highest during the S/G2 phase and then decreasing again -
Isoforms & Post-Translational Modification
O96006: 694 amino acids, molecular weight 78156 Da.
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Subunit
Homodimer and homomultimer (PubMed:17209048)
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SwissProt ID
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Synonyms
ALTE; DREF; hDREF; TRAMP
Documentation
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