Anticancer agent 108

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Anticancer agent 108 (Compound 3.10) is a potent P-gp inhibitor with significant antitumor activity and less toxicity to normal and pseudonormal cells. Anticancer agent 108 (Compound 3.10) had no acute toxic effect on С57BL/6 mice.

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Anticancer agent 108 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	7.09 μM Compound: 3.10	Growth inhibition of human 786-0 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human 786-0 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
A498	GI₅₀	3.48 μM Compound: 3.10	Growth inhibition of human A498 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human A498 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
A549	GI₅₀	1.78 μM Compound: 3.10	Growth inhibition of human A549 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human A549 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
ACHN	GI₅₀	4.08 μM Compound: 3.10	Growth inhibition of human ACHN cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human ACHN cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
BT-549	GI₅₀	1.64 μM Compound: 3.10	Growth inhibition of human BT-549 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human BT-549 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
CAKI-1	GI₅₀	3.29 μM Compound: 3.10	Growth inhibition of human CAKI-1 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human CAKI-1 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
CCRF-CEM	GI₅₀	3.29 μM Compound: 3.10	Growth inhibition of human CCRF-CEM cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human CCRF-CEM cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
COLO 205	GI₅₀	1.89 μM Compound: 3.10	Growth inhibition of human COLO 205 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human COLO 205 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
DU-145	GI₅₀	1.55 μM Compound: 3.10	Growth inhibition of human DU-145 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human DU-145 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
EKVX	GI₅₀	6.75 μM Compound: 3.10	Growth inhibition of human EKVX cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human EKVX cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HCC 2998	GI₅₀	2.5 μM Compound: 3.10	Growth inhibition of human HCC 2998 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human HCC 2998 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HCT-116	GI₅₀	2.37 μM Compound: 3.10	Growth inhibition of human HCT-116 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human HCT-116 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HCT-116	IC₅₀	0.6 μM Compound: 3.10	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
HCT-15	GI₅₀	1.75 μM Compound: 3.10	Growth inhibition of human HCT-15 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human HCT-15 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HL-60	GI₅₀	1.82 μM Compound: 3.10	Growth inhibition of human HL-60 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human HL-60 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HOP-62	GI₅₀	2.04 μM Compound: 3.10	Growth inhibition of human HOP-62 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human HOP-62 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HOP-92	GI₅₀	3.15 μM Compound: 3.10	Growth inhibition of human HOP-92 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human HOP-92 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HT-29	GI₅₀	3.3 μM Compound: 3.10	Growth inhibition of human HT-29 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human HT-29 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
HaCaT	IC₅₀	37.16 μM Compound: 3.10	Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human HaCaT cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
Hs-578T	GI₅₀	2.2 μM Compound: 3.10	Growth inhibition of human Hs-578T cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human Hs-578T cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
IGROV-1	GI₅₀	2.51 μM Compound: 3.10	Growth inhibition of human IGROV-1 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human IGROV-1 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
J774.2	IC₅₀	2.59 μM Compound: 3.10	Cytotoxicity against mouse J774.2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against mouse J774.2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
K562	GI₅₀	2.84 μM Compound: 3.10	Growth inhibition of human K562 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human K562 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
K562	IC₅₀	5.98 μM Compound: 3.10	Cytotoxicity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human K562 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
KB 3-1	IC₅₀	0.75 μM Compound: 3.10	Cytotoxicity against human KB 3-1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human KB 3-1 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
KM12	GI₅₀	3.71 μM Compound: 3.10	Growth inhibition of human KM12 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human KM12 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
LOX IMVI	GI₅₀	2.21 μM Compound: 3.10	Growth inhibition of human LOX IMVI cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human LOX IMVI cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
Lymphocyte	IC₅₀	> 50 μM Compound: 3.10	Cytotoxicity against human Lymphocyte cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human Lymphocyte cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
M14	GI₅₀	1.06 μM Compound: 3.10	Growth inhibition of human M14 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human M14 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
MCF7	GI₅₀	1.39 μM Compound: 3.10	Growth inhibition of human MCF7 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human MCF7 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
MCF7	IC₅₀	3.08 μM Compound: 3.10	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
MDA-MB-231	GI₅₀	2.73 μM Compound: 3.10	Growth inhibition of human MDA-MB-231 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human MDA-MB-231 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
MDA-MB-435	GI₅₀	1.16 μM Compound: 3.10	Growth inhibition of human MDA-MB-435 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human MDA-MB-435 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
MDA-MB-468	GI₅₀	2.01 μM Compound: 3.10	Growth inhibition of human MDA-MB-468 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human MDA-MB-468 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
MOLT-4	GI₅₀	2.71 μM Compound: 3.10	Growth inhibition of human MOLT-4 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human MOLT-4 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
Malme-3M	GI₅₀	0.75 μM Compound: 3.10	Growth inhibition of human Malme-3M cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human Malme-3M cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
NCI-H226	GI₅₀	2.18 μM Compound: 3.10	Growth inhibition of human NCI-H226 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human NCI-H226 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
NCI-H322M	GI₅₀	1.71 μM Compound: 3.10	Growth inhibition of human NCI-H322M cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human NCI-H322M cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
NCI-H460	GI₅₀	1.54 μM Compound: 3.10	Growth inhibition of human NCI-H460 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human NCI-H460 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
NCI-H522	GI₅₀	2.31 μM Compound: 3.10	Growth inhibition of human NCI-H522 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human NCI-H522 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
NCI/ADR-RES	GI₅₀	3.02 μM Compound: 3.10	Growth inhibition of human NCI/ADR-RES cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human NCI/ADR-RES cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
NIH3T3	IC₅₀	6.07 μM Compound: 3.10	Cytotoxicity against mouse NIH3T3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against mouse NIH3T3 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 37001390]
OVCAR-3	GI₅₀	2.86 μM Compound: 3.10	Growth inhibition of human OVCAR-3 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human OVCAR-3 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
OVCAR-4	GI₅₀	1.79 μM Compound: 3.10	Growth inhibition of human OVCAR-4 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human OVCAR-4 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
OVCAR-5	GI₅₀	2.13 μM Compound: 3.10	Growth inhibition of human OVCAR-5 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human OVCAR-5 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
OVCAR-8	GI₅₀	2.46 μM Compound: 3.10	Growth inhibition of human OVCAR-8 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human OVCAR-8 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
PC-3	GI₅₀	2.75 μM Compound: 3.10	Growth inhibition of human PC-3 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human PC-3 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
RPMI-8226	GI₅₀	2.62 μM Compound: 3.10	Growth inhibition of human RPMI-8226 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human RPMI-8226 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
RXF 393	GI₅₀	2.02 μM Compound: 3.10	Growth inhibition of human RXF 393 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human RXF 393 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SF-268	GI₅₀	3.48 μM Compound: 3.10	Growth inhibition of human SF-268 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SF-268 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SF-295	GI₅₀	1.98 μM Compound: 3.10	Growth inhibition of human SF-295 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SF-295 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SF-539	GI₅₀	1.93 μM Compound: 3.10	Growth inhibition of human SF-539 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SF-539 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SK-MEL-2	GI₅₀	3.51 μM Compound: 3.10	Growth inhibition of human SK-MEL-2 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SK-MEL-2 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SK-MEL-28	GI₅₀	1.87 μM Compound: 3.10	Growth inhibition of human SK-MEL-28 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SK-MEL-28 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SK-MEL-5	GI₅₀	1.59 μM Compound: 3.10	Growth inhibition of human SK-MEL-5 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SK-MEL-5 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SK-OV-3	GI₅₀	15.5 μM Compound: 3.10	Growth inhibition of human SK-OV-3 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SK-OV-3 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SN12C	GI₅₀	1.74 μM Compound: 3.10	Growth inhibition of human SN12C cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SN12C cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SNB-19	GI₅₀	2.6 μM Compound: 3.10	Growth inhibition of human SNB-19 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SNB-19 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SNB-75	GI₅₀	3.17 μM Compound: 3.10	Growth inhibition of human SNB-75 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SNB-75 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SR	GI₅₀	3.05 μM Compound: 3.10	Growth inhibition of human SR cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SR cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
SW-620	GI₅₀	3.28 μM Compound: 3.10	Growth inhibition of human SW620 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human SW620 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
T47D	GI₅₀	2.87 μM Compound: 3.10	Growth inhibition of human T47D cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human T47D cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
TK-10	GI₅₀	12.3 μM Compound: 3.10	Growth inhibition of human TK-10 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human TK-10 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
U-251	GI₅₀	3.07 μM Compound: 3.10	Growth inhibition of human U-251 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human U-251 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
UACC-257	GI₅₀	1.57 μM Compound: 3.10	Growth inhibition of human UACC-257 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human UACC-257 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
UACC-62	GI₅₀	1.76 μM Compound: 3.10	Growth inhibition of human UACC-62 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human UACC-62 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]
UO-31	GI₅₀	2.56 μM Compound: 3.10	Growth inhibition of human UO-31 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay Growth inhibition of human UO-31 cells incubated for 48 hrs by sulforhodamine B spectrophotometric assay	[PMID: 37001390]

In Vitro

Anticancer agent 108 (10 μM; 48 h) significantly inhibits the proliferation of cancer cells^[1].
Anticancer agent 108 (50, 100, 250, 500 nM; 72 h) inhibits the proliferation of KB-3-1 cells^[1].
Anticancer agent 108 (0.5, 2.5, 5 μM; 3, 24 h) uses endoplasmic reticulum (ER) stress to induce apoptosis^[1].
Anticancer agent 108 (5, 10 μM; 24 h) induces apoptosis of MDA-MB-231 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	60 cancer cell lines representing nine different types (leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and breast cancers)
Concentration:	10 μM
Incubation Time:	48 h
Result:	Possessed prominent antitumor activity (mean growth −61.06%; the range of growth −99.55 to 18.52). In addition, inhibited the growth of 25 tested cancer cell lines with percent growth of <0, and showed not only cytostatic effect but also cytotoxic properties.

Cell Proliferation Assay^[1]

Cell Line:	KB-3-1 cells
Concentration:	50, 100, 250, 500 nM
Incubation Time:	72 h
Result:	Almost 14 times bigger comparing to survival fraction after incubation of KB-3-1 cells with doxorubicin in the same concentration (100 nM) used as a positive control. However, at applying 500 nM concentration, did not observe the growth of KB-3-1 cell colonies after 72 h of drug exposure.

Western Blot Analysis^[1]

Cell Line:	KB-3-1 cells
Concentration:	0.5, 2.5, 5 μM
Incubation Time:	3, 24 h
Result:	Dose-dependently increased the expression of BIP (immunoglobulin heavy chain binding protein) at 24 hours, while no changes in the levels of the above proteins were found at 3 hours.

Apoptosis Analysis^[1]

Cell Line:	MDA-MB-231 breast cancer cells
Concentration:	5, 10 μM
Incubation Time:	24 h
Result:	Induced apoptosis in the MDA-MB-231 breast cancer cells proceeding through two pathways, extrinsic and intrinsic.

In Vivo

Anticancer agent 108 (single dose, i.p. 20 mg/kg) does not induce a loss of body mass in animals, their rapid death, leukopenia, erythropenia, and a decrease in the level of hemoglobin in blood of mice.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	С57BL/6 mice^[1]
Dosage:	20 mg/kg
Administration:	single dose, i.p. 20 mg/kg
Result:	Did not induce a loss of body mass in animals, their rapid death, leukopenia, erythropenia, and a decrease in the level of hemoglobin in blood of mice.

Molecular Weight

383.40

Formula

C₁₈H₉NO₅S₂

SMILES

O=C1NC2=C(C(C3=C(C(C4=C(C(O)=CC=C4)C3=O)=O)S2)C5=CC=CO5)S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ivasechko I, et al. Molecular design, synthesis and anticancer activity of new thiopyrano[2,3-d]thiazoles based on 5-hydroxy-1,4-naphthoquinone (juglone). Eur J Med Chem. 2023 Apr 5;252:115304. [Content Brief]