Art. -Nr.: HY-B0006A

Carvedilol phosphate hemihydrate

(Synonyms: BM 14190 phosphate hemihydrate)

13 Cited Publications

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Based on 13 publication(s) in Google Scholar

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC₅₀ of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome.

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Reinheit: 99.94%
CAS. Nr.: 610309-89-2
Formel: C₂₄H₂₆N₂O₄.H₃PO₄.1/2H₂O
Molecular Weight:513.48

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Carvedilol phosphate hemihydrate Chemical Structure

CAS. Nr.: 610309-89-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (13)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) is a non-selective β/α-1 blocker^[1]. Carvedilol phosphate hemihydrate inhibits lipid peroxidation with an IC₅₀ of 5 μM. Carvedilol phosphate hemihydrate is a multiple action antihypertensive agent with potential use in angina and congestive heart failure^[2]. Carvedilol phosphate hemihydrate is an autophagy inducer that inhibits the NLRP3 inflammasome^[3].

IC₅₀ & Target

β/α-1 adrenergic receptor^[1]
IC50: 5 μM (lipid peroxidation)^[2]
Autophagy^[3]

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Superoxide generation by activated human neutrophils in vitro is inhibited by Carvedilol with an IC₅₀ of 28 μM. Carvedilol is shown to scavenge oxygen free radicals in a cell-free system with an IC₅₀ of 25 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 610309-89-2
Appearance Solid
Molecular Weight 513.48
Formel C₂₄H₂₆N₂O₄.H₃PO₄.1/2H₂O
Color White to off-white
SMILES

O=P(O)(O)O.OC(CNCCOC1=C(OC)C=CC=C1)COC2=CC=CC3=C2C4=C(C=CC=C4)N3.O.[1/2]
Synonyms

BM 14190 phosphate hemihydrate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (13)

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Journal Impact Factor

Redox Biol

Oxidative stress promotes lipid-laden macrophage formation via CYP1B1. [Abstract]

2024 Dec 21:79:103481. PMID: 39721495

Carvedilol phosphate hemihydrate purchased from MedChemExpress. Usage Cited in: Redox Biol. 2024 Dec 21:79:103481. [Abstract]

U937 macrophages cultured with or without 5 % CSE were treated with 5 μM, 10 μM, or 20 μM Carvedilol (Carv) for 3 days. LLM formation was determined using ORO staining.
Free Radic Biol Med

IL-6/gp130/STAT3 signaling contributed to the activation of the PERK arm of the unfolded protein response in response to chronic β-adrenergic stimulation. [Abstract]

2023 Aug 20:205:163-174. PMID: 37307935
Cell Rep

Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity. [Abstract]

2025 Apr 16;44(5):115572. PMID: 40249703

Carvedilol phosphate hemihydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 16;44(5):115572. [Abstract]

Real-time qPCR measurement of Ifnb1 and Cxcl10 transcripts in mouse peritoneal macrophages treated with cGAMP (1 μg/mL) and Digitonin (10 μg/mL) for indicated times in the presence of DMSO or Carvedilol (10 μM).

Carvedilol phosphate hemihydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 16;44(5):115572. [Abstract]

ELISA of IFN-β and CXCL10 production in mouse peritoneal macrophages treated with cGAMP or ISD for 12 h in the presence of DMSO or Carvedilol (10 μM).

Carvedilol phosphate hemihydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 16;44(5):115572. [Abstract]

Immunoblotting of the indicated signaling molecules in mouse peritoneal macrophages treated with cGAMP or ISD in the presence of DMSO or Carvedilol (10 μM) for indicated times.

Carvedilol phosphate hemihydrate purchased from MedChemExpress. Usage Cited in: Cell Rep. 2025 Apr 16;44(5):115572. [Abstract]

Carvedilol (10 μM) enhanced HA-STING but not HA-STING^T263A localizing to ERGIC by Immunofluorescence assay.
Cell Rep

Pharmacological boosting of cGAS activation sensitizes chemotherapy by enhancing antitumor immunity. [Abstract]

2023 Mar 20;42(3):112275. PMID: 36943864
J Pathol

Novel prognostication biomarker adipophilin reveals a metabolic shift in uveal melanoma and new therapeutic opportunities. [Abstract]

2023 Jun;260(2):203-221. PMID: 36825655
Cells

Redistribution of the SWI/SNF Complex Dictates Coordinated Transcriptional Control over Epithelial-Mesenchymal Transition of Normal Breast Cells through TGF-β Signaling. [Abstract]

2022 Aug 24;11(17):2633. PMID: 36078038
ACS Omega

Computational and Experimental Approaches Identify Beta-Blockers as Potential SARS-CoV-2 Spike Inhibitors. [Abstract]

2022 Aug 8;7(32):27950-27958. PMID: 35983371
Biochim Biophys Acta Mol Basis Dis

Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2. [Abstract]

2025 Jun;1871(5):167754. PMID: 40044066
J Nat Prod

Spirocyclic Adduct Formation of Tryptanthrin with Indole Monoamines under Biomimetic Acidic Conditions. [Abstract]

2026 Feb 27;89(2):645-655. PMID: 41680098
J Diabetes Res

Diabetic Cardiomyopathy Uncovered: Transcriptomics, NLRP3, and Carvedilol Mechanisms. [Abstract]

2024 Nov 23:2024:9378405. PMID: 39619569
Cardiooncology

Breast cancer progression in the presence of treated and untreated left ventricular dysfunction. [Abstract]

2025 Nov 13;11(1):106. PMID: 41233850
Comput Biol Chem

Targeting quorum sensing in Pseudomonas aeruginosa with high-affinity inhibitors: A high-throughput screening and in-silico analysis. [Abstract]

2025 Aug:117:108419. PMID: 40088808
J Pharm Biomed Anal

Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]

2021 Feb 20:195:113870. PMID: 33453569

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (194.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9475 mL

9.7375 mL

19.4750 mL

5 mM

0.3895 mL

1.9475 mL

3.8950 mL

10 mM

0.1947 mL

0.9737 mL

1.9475 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Konzentration

Volumen

Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)}

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Animal Weight (Per Animal)
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Dosing Volume (Per Animal)
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Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (537 KB)
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- Deutsch - DE (537 KB)
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- Portuguese - PT (537 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22. [Content Brief]

[2]. Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8. [Content Brief]

[3]. Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9475 mL	9.7375 mL	19.4750 mL	48.6874 mL
	5 mM	0.3895 mL	1.9475 mL	3.8950 mL	9.7375 mL
	10 mM	0.1947 mL	0.9737 mL	1.9475 mL	4.8687 mL
	15 mM	0.1298 mL	0.6492 mL	1.2983 mL	3.2458 mL
	20 mM	0.0974 mL	0.4869 mL	0.9737 mL	2.4344 mL
	25 mM	0.0779 mL	0.3895 mL	0.7790 mL	1.9475 mL
	30 mM	0.0649 mL	0.3246 mL	0.6492 mL	1.6229 mL
	40 mM	0.0487 mL	0.2434 mL	0.4869 mL	1.2172 mL
	50 mM	0.0389 mL	0.1947 mL	0.3895 mL	0.9737 mL
	60 mM	0.0325 mL	0.1623 mL	0.3246 mL	0.8115 mL
	80 mM	0.0243 mL	0.1217 mL	0.2434 mL	0.6086 mL
	100 mM	0.0195 mL	0.0974 mL	0.1947 mL	0.4869 mL

Carvedilol phosphate hemihydrate

13 Cited Publications

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Carvedilol phosphate hemihydrate

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Publications Citing Use of MedChemExpress (MCE) Carvedilol phosphate hemihydrate

Alle Adrenergic Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (13)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Carvedilol phosphate hemihydrate Related Classifications

Art. -Nr.: HY-B0006A