AChE/BuChE-IN-7
AChE/BuChE-IN-7 is a dual-action inhibitor with an IC50 valueof 0.15 μM for AChE and 0.7 μM for BuChE, SI of 4.7. AChE/BuChE-IN-7 shows anti-oxidant activity and can mitigate H2O2-induced cytotoxicity. AChE/BuChE-IN-7 has genomic stability and prolonged systemic availability. AChE/BuChE-IN-7 can be used for the research of neurological disease, such as Alzheimer's disease.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C25H34N2O3
- Molecular Weight:410.55
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
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AChE 0.15 μM (IC50) |
BuChE 0.7 μM (IC50) |
AChE/BuChE-IN-7 (Compound D9) (10-80 μM, 24 h) shows low cytotoxicity in HT-22 murine hippocampal neuronal cells, with an IC50 >80 μM[1].
AChE/BuChE-IN-7 (5-20 μM, 4 h before H2O2) exerts significant neuroprotective effects against H2O2-induced oxidative stress injury in HT-22 cells[1].
AChE/BuChE-IN-7 (5-400 μM) exhibits potent DPPH radical scavenging and ferrous ion chelation activity with IC50 values of 46.9 and 15.7 μM[1].
AChE/BuChE-IN-7 (0-200 μM) shows moderate DNA binding affinity and the ability to maintain genomic stability HT-22 cells[1].
AChE/BuChE-IN-7 (0-250 μM) binds to human serum albumin (HSA) via a static quenching mechanism and prolongs the circulation time[1].
AChE/BuChE-IN-7 binds to Alzheimer's disease-related targets with high affinity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT-22 murine hippocampal neuronal cells
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Concentration:10, 20. 40 and 80 μM
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Incubation Time:24 h
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Result:Maintained cell viability >80%.
Chemical Information
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Molecular Weight 410.55
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Formel C25H34N2O3
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SMILES
O=C(N1N=C(C)C=C1C)O[C@H](CC2=CC[C@@]3([H])[C@]4([H])CC5)CC[C@]2(C)[C@@]3([H])CC[C@]4(C)C5=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
AChE/BuChE-IN-7 Related Classifications
HY-178141 Related Classifications
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