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Art. -Nr.: HY-103052

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CGS-9896

CGS-9896 is an orally active benzodiazepine receptor agonist that targets the benzodiazepine receptor allosterically coupled to the GABA_A receptor and chloride ion carrier channel. The K_i value of CGS-9896 for benzodiazepine receptors in rats is 0.83 nM. CGS-9896 inhibits pentylenetetrazol-induced convulsions in mice and exerts an anticonvulsant effect.

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CAS. Nr.: 77779-36-3
Formel: C₁₆H₁₀ClN₃O
Molecular Weight:295.73

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGS-9896 Chemical Structure

CAS. Nr.: 77779-36-3

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

CGS-9896 (1.17 mg/kg; p.o.) acts an ED₅₀ of 1.17 mg/kg p.o. for preventing pentylenetetrazole-induced convulsions in male mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male mice^[1]
Dosage:

1.17 mg/kg
Administration:

p.o.
Result:

Exhibited agonist (anticonvulsant) activity with an ED₅₀ of 1.17 mg/kg, representing the dose required to prevent tonic convulsions and death in 50% of treated mice.

Chemical Information

CAS. Nr. 77779-36-3
Molecular Weight 295.73
Formel C₁₆H₁₀ClN₃O
SMILES

O=C1C2=CNC=3C=CC=CC3C2=NN1C4=CC=C(Cl)C=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Takada S, et al.. Synthesis and structure--activity relationships of fused imidazopyridines: a new series of benzodiazepine receptor ligands. Journal of medicinal chemistry. 1996 Jul 05;39(14):2844-51. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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