DPPE-PEG2000-cRGD

DPPE-PEG2000-cRGD is specifically designed for active targeting nanomedicine applications. It can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against αvβ3/αvβ5 integrins on tumor vasculature and cancer cell surfaces.
Composition and role of each component:
1. DPPE (dipalmitoylphosphatidylethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchorage; its saturated C16 chains confer bilayer rigidity.
2. PEG2000 (polyethylene glycol, MW 2000): Hydrophilic polymer spacer arm that forms a steric corona around nanoparticles, reducing opsonization and reticuloendothelial system (RES) clearance, prolonging circulation half-life, and providing spatial separation between the lipid surface and targeting ligand.
3. cRGD (cyclic RGD peptide (cyclo(Arg-Gly-Asp))): Targeting ligand-a cyclic peptide containing the arginine-glycine-aspartic acid (RGD) motif that selectively binds to αvβ3 and αvβ5 integrins, which are highly expressed on tumor neovasculature, activated endothelial cells, and certain cancer cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.