SLC39A6 - solute carrier family 39 member 6 Gene

Also Known as LIV1; ZIP6; LIV-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25800

About SLC39A6

Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38): 18:36,108,531-36,129,340 (from NCBI)

This gene has 4 transcripts (splice variants), 210 orthologues and 6 paralogues. Broad expression in prostate (RPKM 62.4), endometrium (RPKM 31.1) and 24 other tissues.

Summary

Zinc is an essential cofactor for hundreds of Enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

SLC39A6 Products (2)

mRNA	Protein	Name
NM_001099406.2	NP_001092876.1	zinc transporter ZIP6 isoform 2
NM_012319.4	NP_036451.4	zinc transporter ZIP6 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27274087	GOA
enables zinc ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	15642354	GOA
enables zinc ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	30552163	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	34394081	GOA
involved in epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	23919497	GOA
involved in intracellular zinc ion homeostasis	IDA IDA: Inferred from direct assay	15642354	GOA
involved in lymphocyte activation	IMP IMP: Inferred from mutant phenotype	30552163	GOA
involved in zinc ion import across plasma membrane	IDA IDA: Inferred from direct assay	15642354	GOA
involved in zinc ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	30552163	GOA
involved in zinc ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	12839489	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in lamellipodium membrane	IDA IDA: Inferred from direct assay	12839489	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	34394081	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12839489	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A6 Protein Structure

Zip

0
200
400
600
755 a.a.

Protein Preferred Names	Protein Names
zinc transporter ZIP6	LIV-1 protein, estrogen regulated

Recombinant SLC39A6 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P78748	LIV-1/SLC39A6 Protein, Human (HEK293, Fc)	Q13433-1 (F29-W325)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78749	LIV-1/SLC39A6 Protein, Human (HEK293, His)	Q13433-1 (F29-W325)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P78806	LIV-1/SLC39A6 Protein, Human (Biotinylated, HEK293, His-Avi)	Q13433-1 (F29-W325)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P700463	LIV-1/SLC39A6 Protein, Human (sf9, His)	Q13433-1 (F29-W325)	≥ 95%, as determined by reducing SDS-PAGE.

SLC39A6 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P81442	SLC39A6 Antibody (YA1187)	IHC-P	Human
HY-P81442A	SLC39A6 Antibody (YA1187)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Acrodermatitis Enteropathica AEZ Enteropathica Brandt Syndrome Ae Acrodermatitis Enteropathica Zinc Deficiency Type Danbolt-Cross Syndrome Acrodermatitis Enteropathica, Zinc Deficiency Type Inherited Zinc Deficiency Acrodermatitis Enteropathica, Zinc Deficiency Danbolt-Closs Syndrome Primary Zinc Malabsorption Syndrome
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3	Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like Scd-Eds EDSSPD3 Ehlers-Danlos Syndrome Spondylodysplastic Type 3 Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome Slc39a13-Related Speds Slc39a13-Related Spondylodysplastic Eds Spondylocheirodysplastic Ehlers-Danlos Syndrome Speds-Slc39a13 Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Hemophagocytic Lymphohistiocytosis, Familial, 1	Familial Hemophagocytic Lymphohistiocytosis Fhl Familial Erythrophagocytic Lymphohistiocytosis Hemophagocytic Syndrome FHL1 Hplh1 Hlh1 Fel Familial Hemophagocytic Lymphohistiocytosis 1 Primary Hemophagocytic Lymphohistiocytosis Familial Hlh Hlh Familial Hemophagocytic Lymphocytosis Hemophagocytic Lymphohistiocytosis, Familial Reticulosis, Familial Histiocytic Hemophagocytic Reticulosis, Familial Erythrophagocytic Lymphohistiocytosis, Familial Familial Histiocytic Reticulosis Familial Hemophagocytic Histiocytosis Familial Hemophagocytic Reticulosis Fhlh Hplh Primary Hemophagocytic Hymphohistiocytosis Genetic Hemophagocytic Lymphohistiocytosis Hemophagocytic Lymphohistiocytosis Familial Hemophagocytic Lymphohistiocytosis Type 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ehlers-Danlos Syndrome	Eds Cutis Hyperelastica Elastic Skin Ehlers-Danlos Syndromes Ed Syndrome Ehlers Danlos Syndrome Ehlers Danlos Disease Eds - [Ehlers-Danlos Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13237	SLC39A6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20646	Slc39a6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27157	Slc39a6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P991145	Laventatug	Inhibitor	95.534%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC39A6	VGNC	VGNC:34866
Canis familiaris	SLC39A6	VGNC	VGNC:46405
Macaca mulatta	SLC39A6	VGNC	VGNC:77508
Mus musculus	SLC39A6	MGD	MGI:2147279
Rattus norvegicus	SLC39A6	RGD	RGD:1304664
Felis catus	SLC39A6	VGNC	VGNC:65362
Others	SLC39A6	NCBI