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  5. SLC39A6 Antibody (YA1187)(PBS only)

SLC39A6 Antibody (YA1187)(PBS only)

Art. -Nr.: HY-P81442A
User Guide for Antibodies Technical Support

SLC39A6 Antibody (YA1187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC39A6.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Beschreibung

  • Verweise

Beschreibung

SLC39A6 Antibody (YA1187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC39A6.
Host

Rabbit
Molekulargewicht

The human full length SLC39A6 protein has a MW of 84.9 kDa
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human SLC39A6
Application &
Dilution Ratio
Application Dilution Ratio
IHC-P
IHC-P: Immunohistochemistry-Paraffin
100-1:200
Reinheit Affinity Purified Conjugation Non-conjugated
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in PBS, pH 7.4.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Versand

Shipping with blue ice.
Background
Function：Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461)
Subcellular Localization：Cell membrane; Multi-pass membrane protein; Cell projection, lamellipodium membrane; Multi-pass membrane protein; Membrane raft; Multi-pass membrane protein; Apical cell membrane
Expression：
Tissue_specificity:Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum (PubMed:12839489) . Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma (PubMed:12839489)

Induction:Up-regulated by estrogen in breast cancer cells lines (PubMed:23919497, PubMed:2903103) . Decreased protein level in response to zinc treatment (PubMed:18272141) . Increased upon T cell activation (PubMed:30552163) . Induced by STAT3 (PubMed:23919497)
Isoforms & Post-Translational Modification：Q13433 has 2 isomers: Q13433-1: 85047 Da (predicted); Q13433-2: 48605 Da (predicted).
Cleaved on the N-terminus before locating to the plasma membrane;N-glycosylated;Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation
Subunit：Interacts with SLC39A10; which triggers cells to undergo EMT and mitosis (PubMed:27274087). Found in a complex with SLC39A6, SLC39A10 and with the 'Ser-727' phosphorylated form of STAT3 throughout mitosis (PubMed:32797246). Found in a complex with SLC39A6, SLC39A10 and with NCAM1; this complex controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition (EMT) (By similarity). Found in a complex with SLC39A6, SLC39A10 and with GSK3B that controls NCAM1 phosphorylation (By similarity)
Research Field

Signal Transduction
Synonyms
LIV-1; ZIP-6
Dokumentation
User Guide for Antibodies (1077 KB)
Verweise

SLC39A6 Antibody (YA1187)(PBS only) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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