SLC39A6 Antibody (YA1187)
(Synonyms: LIV-1; ZIP-6)SLC39A6 Antibody (YA1187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC39A6.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 100-1:200 |
Product Details
SLC39A6 Antibody (YA1187) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SLC39A6.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight The human full length SLC39A6 protein has a MW of 84.9 kDa
A synthesized peptide derived from human SLC39A6
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLC39A6 is a Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT. Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence. In addition, the SLC39A10-SLC39A6 heterodimer plays an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis. Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes. Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition[1][2][3][4][5][6][7][8][9].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Cell projection, lamellipodium membrane; Multi-pass membrane protein; Membrane raft; Multi-pass membrane protein; Apical cell membrane
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Expression
Tissue_specificity:Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum (PubMed:12839489) . Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma (PubMed:12839489)
Induction:Up-regulated by estrogen in breast cancer cells lines (PubMed:23919497, PubMed:2903103) . Decreased protein level in response to zinc treatment (PubMed:18272141) . Increased upon T cell activation (PubMed:30552163) . Induced by STAT3 (PubMed:23919497) -
Isoforms & Post-Translational Modification
Q13433 has 2 isomers: Q13433-1: 85047 Da (predicted); Q13433-2: 48605 Da (predicted).
Cleaved on the N-terminus before locating to the plasma membrane;N-glycosylated;Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation -
Subunit
Interacts with SLC39A10; which triggers cells to undergo EMT and mitosis (PubMed:27274087). Found in a complex with SLC39A6, SLC39A10 and with the 'Ser-727' phosphorylated form of STAT3 throughout mitosis (PubMed:32797246). Found in a complex with SLC39A6, SLC39A10 and with NCAM1; this complex controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition (EMT) (By similarity). Found in a complex with SLC39A6, SLC39A10 and with GSK3B that controls NCAM1 phosphorylation (By similarity)
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SwissProt ID
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Synonyms
LIV-1; ZIP-6
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Research Field
Signal Transduction
Documentation
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