TNFAIP8 - TNF alpha induced protein 8 Gene

Also Known as NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25816

About TNFAIP8

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:119,268,759-119,399,688 (from NCBI)

This gene has 7 transcripts (splice variants), 131 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues.

Summary

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNFAIP8 Products (6)

mRNA Protein Name
NM_001077654.3 NP_001071122.1 tumor necrosis factor alpha-induced protein 8 isoform b
NM_001286813.2 NP_001273742.1 tumor necrosis factor alpha-induced protein 8 isoform a
NM_001286814.1 NP_001273743.1 tumor necrosis factor alpha-induced protein 8 isoform c
NM_001286815.2 NP_001273744.1 tumor necrosis factor alpha-induced protein 8 isoform d
NM_001286817.2 NP_001273746.1 tumor necrosis factor alpha-induced protein 8 isoform d
NM_014350.4 NP_055165.2 tumor necrosis factor alpha-induced protein 8 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
10644768 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10644768 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14724590 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP8 Protein Structure

DUF758

DUF758: Domain of unknown function (DUF758) (14 - 198)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor alpha-induced protein 8

  • NF-kappa-B-inducible DED-containing protein

TNFAIP8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
TNFAIP8 O95379 ATN1 Homo sapiens Q86V38
Y2H Prey Pooling
32296183
Intra
TNFAIP8 O95379 ATN1 Homo sapiens Q86V38
Validated Y2H
32296183
Intra
TNFAIP8 O95379 ATN1 Homo sapiens Q86V38
Y2H Array
32296183
Intra
TNFAIP8 O95379 MED4 Homo sapiens Q9NPJ6
Y2H Pooling
16189514
Intra
TNFAIP8 O95379 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
25416956
Intra
TNFAIP8 O95379 MED4 Homo sapiens Q9NPJ6
Validated Y2H
25416956
Intra
TNFAIP8 O95379 MED4 Homo sapiens Q9NPJ6
Y2H Prey Pooling
32296183
Intra
TNFAIP8 O95379 MED4 Homo sapiens Q9NPJ6
Validated Y2H
32296183
Intra
TNFAIP8 O95379 MED4 Homo sapiens Q9NPJ6
Y2H Array
32296183
Intra
TNFAIP8 O95379 SDCBP Homo sapiens O00560
Y2H Array
25416956
Intra
TNFAIP8 O95379 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
TNFAIP8 O95379 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
TNFAIP8 O95379 TIFA Homo sapiens Q96CG3
Validated Y2H
25416956
Intra
TNFAIP8 O95379 TIFA Homo sapiens Q96CG3
Y2H Array
25416956
Intra
TNFAIP8 O95379 PRR13 Homo sapiens Q9NZ81
Y2H Prey Pooling
25416956
Intra
TNFAIP8 O95379 PRR13 Homo sapiens Q9NZ81
Validated Y2H
32296183
Intra
TNFAIP8 O95379 PRR13 Homo sapiens Q9NZ81
Y2H Array
25416956
Intra
TNFAIP8 O95379 PLEKHF1 Homo sapiens Q96S99
Validated Y2H
32296183
Intra
TNFAIP8 O95379 PLEKHF1 Homo sapiens Q96S99
Y2H Prey Pooling
32296183
Intra
TNFAIP8 O95379 PLEKHF1 Homo sapiens Q96S99
Y2H Array
32296183
Intra
TNFAIP8 O95379 EAPP Homo sapiens Q56P03
Validated Y2H
32296183
Intra
TNFAIP8 O95379 EAPP Homo sapiens Q56P03
Y2H Array
32296183
Intra
TNFAIP8 O95379 EAPP Homo sapiens Q56P03
Y2H Prey Pooling
32296183
Intra
TNFAIP8 O95379 EAF1 Homo sapiens Q96JC9
Validated Y2H
32296183
Intra
TNFAIP8 O95379 INO80E Homo sapiens Q8NBZ0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFAIP8 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P76682 TNFAIP8 Protein, Human (His) O95379-1 (M1-I198) ≥ 95%, as determined by reducing SDS-PAGE.

TNFAIP8 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81855 TNFAIP8 Antibody (YA1600) WB, IP Human
HY-P81855A TNFAIP8 Antibody (YA1600)(PBS only) WB, IP Human

Related Diseases

Diseases Alias
Plantar Fasciitis

  • Fasciitis, Plantar
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS14791 TNFAIP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14792 TNFAIP8L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14793 TNFAIP8L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14794 TNFAIP8L3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19287 Tnfaip8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25777 Tnfaip8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNFAIP8 RGD RGD:1305908
Felis catus TNFAIP8 VGNC VGNC:102349
Bos taurus TNFAIP8 VGNC VGNC:36157
Mus musculus TNFAIP8 MGD MGI:2147191
Macaca mulatta TNFAIP8 VGNC VGNC:79068
Canis familiaris TNFAIP8 VGNC VGNC:47652
Others TNFAIP8 NCBI