HAVCR1 - hepatitis A virus cellular receptor 1 Gene

Also Known as TIM; KIM1; TIM1; CD365; HAVCR; KIM-1; TIM-1; TIMD1; TIMD-1; HAVCR-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26762

About HAVCR1

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,029,413-157,069,407 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 3 paralogues. Biased expression in kidney (RPKM 1.3), colon (RPKM 1.2) and 6 other tissues.

Summary

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple Other viruses, including Ebola virus, Marburg virus, Dengue Virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and Other coronaviruses. [provided by RefSeq, Sep 2021]

HAVCR1 Products (3)

mRNA Protein Name
NM_001173393.3 NP_001166864.1 hepatitis A virus cellular receptor 1 isoform a precursor
NM_001308156.2 NP_001295085.1 hepatitis A virus cellular receptor 1 isoform b precursor
NM_012206.3 NP_036338.2 hepatitis A virus cellular receptor 1 isoform a precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32995803 GOA
enables virus receptor activity IDA
IDA: Inferred from direct assay
21536871 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in motile cilium IDA
IDA: Inferred from direct assay
21536871 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAVCR1 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (26 - 111)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

hepatitis A virus cellular receptor 1

  • T cell immunoglobin domain and mucin domain protein 1

HAVCR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Cross
HAVCR1 Q96D42 S SARS-CoV-2 P0DTC2
Anti Bait CoIP
33493263
Cross
HAVCR1 Q96D42 S SARS-CoV-2 P0DTC2
MST
32995803
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HAVCR1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P73604 TIM-1/KIM-1/HAVCR Protein, Human (HEK293, His-Fc) AAC39862 (S21-G290) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73605 TIM-1/KIM-1/HAVCR Protein, Human (HEK293) AAC39862 (S21-G290) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P73606 TIM-1/KIM-1/HAVCR Protein, Human (270a.a, HEK293, His) AAC39862 (S21-G290) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73607 TIM-1/KIM-1/HAVCR Protein, Human (135a.a, HEK293, His) AAC39862 (S21-V135) ≥ 95%, as determined by reducing SDS-PAGE.

HAVCR1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81186 TIM 1 Antibody (YA3545) WB Human, Mouse, Rat
HY-P81186A TIM 1 Antibody (YA3545)(PBS only) WB Human, Mouse, Rat
HY-P84722 TIM 1 Antibody (YA4419) WB, ELISA Human, Mouse
HY-P84722A TIM 1 Antibody (YA4419)(PBS only) WB, ELISA Human, Mouse

Related Diseases

Diseases Alias
Hepatitis

  • Chronic Hepatitis

  • Chronic Persistent Hepatitis

  • Acute Hepatitis

  • Hepatitis, Chronic

  • Acute And Subacute Liver Necrosis

  • Acute/Subac. Necrosis Of Liver

  • Animal Hepatitis

  • Hepatitis Chronic

  • Hepatitis A

  • Hepatitis, Animal

  • Hepatitis Due To Toxoplasmosis

  • Hepatitis In Toxoplasmosis

  • Toxoplasmal Hepatitis

  • Chronic Hepatitis, Unspecified

  • Chronic Active Hepatitis Nec

  • Other Specified Chronic Hepatitis

  • Chronic Persistent Hepatitis Nec

  • Chronic Lobular Hepatitis Nec
Hepatitis A

  • Viral Hepatitis A

  • Viral Hepatitis, Type A
Dengue Virus

  • Dengue Virus, Susceptibility To

  • Dengue Fever, Protection Against

  • Dengue Fever
Chikungunya

  • Chikungunya Fever

  • Arbovirus A Chikungunya Type

  • Chik

  • Chikv Infection

  • Ck

  • Chikungunya Virus Infection

  • Chikungunya Haemorrhagic Fever

  • Chikungunya Viral Disease

  • Chikungunya Mosquito-Borne Viral Fever
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Acute Kidney Tubular Necrosis

  • Acute Tubular Necrosis

  • Acute Renal Failure With Tubular Necrosis

  • Acute Tubule Necrosis

  • Acute Renal Failure With Lesion Of Tubular Necrosis

  • Atn - Acute Tubular Necrosis

  • Tubular Necrosis Acute

  • Kidney Tubular Necrosis, Acute

  • Acute Renal Tubular Necrosis

  • Acute Tubular Nephrosis

  • Ischaemic Acute Tubular Necrosis

  • Ischaemic Tubular Necrosis

  • Kidney Tubular Necrosis

  • Lower Nephron Nephrosis

  • Necrotising Renal Oedema

  • Renal Tubular Necrosis

  • Toxic Tubular Necrosis

  • Tubular Kidney Necrosis

  • Tubular Necrosis Nos

  • Tubular Nephrosis
Allergic Asthma

  • Atopic Asthma

  • Extrinsic Asthma

  • Extrinsic Asthma With Acute Exacerbation

  • Extrinsic Asthma With Status Asthmaticus

  • Asthma Allergic

  • Atopic Asthma, Susceptibility To

  • Ige-Mediated Allergic Asthma

  • Allergen-Induced Asthma

  • Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma

  • Allergic Asthma Nos

  • Catarrh With Asthma

  • Allergic Bronchitis Nos

  • Extrinsic Allergic Asthma

  • Predominantly Allergic Asthma With Stated Status Asthmaticus
Scrub Typhus

  • Tsutsugamushi Disease

  • Tsutsugamushi Fever

  • Typhus Fever Due To Rickettsia Tsutsugamushi

  • Chigger-Borne Rickettsiosis

  • Chigger-Borne Typhus

  • Japanese River Fever

  • Kedani Fever

  • Mite-Borne Rickettsiosis

  • Mite-Borne Typhus

  • Scrub Typhus

  • Scrub Mite-Borne Typhus

  • Tropical Typhus

  • Tsutsugamushi
Allergic Rhinitis

  • Hay Fever

  • Allergic Rhinitis, Susceptibility To

  • ALRH

  • Atopic Rhinitis

  • Seasonal Allergic Rhinitis

  • Non-Seasonal Allergic Rhinitis

  • Perenial Allergic Rhinitis

  • Pollenosis

  • Rhinitis Allergic Seasonal

  • Rhinitis, Allergic, Perennial

  • Allergic Rhinitis, Cause Unspecified

  • Pollinosis

  • Pollen Allergy

  • Allergy Nos Due To Pollen

  • Summer Catarrh

  • Other Seasonal Allergic Rhinitis
Ventricular Tachycardia, Catecholaminergic Polymorphic, 4

  • Catecholaminergic Polymorphic Ventricular Tachycardia 4

  • CPVT4

  • Bidirectional Tachycardia

  • Stress-Induced Polymorphic Ventricular Tachycardia

  • Cvpt4

  • Double Tachycardia Induced By Catecholamines

  • Malignant Paroxysmal Ventricular Tachycardia

  • Multifocal Ventricular Premature Beats

  • Paroxysmal Ventricular Fibrillation

  • Syncopal Paroxysmal Tachycardia

  • Syncopal Tachyarythmia

  • Vtsip

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 4

  • Multifocal Pvcs

  • Multifocal Premature Ventricular Beats

  • Paroxysmal Familial Ventricular Fibrillation

  • Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Pyuria

  • Pus Cells In Urine
Type 1 Diabetes Mellitus 19

  • Diabetes Mellitus, Insulin-Dependent, 19

  • IDDM19

  • T1D19

  • Insulin-Dependent Diabetes Mellitus 19
Hyperuricemia

  • Blood Urate Raized

  • Uricacidemia
Congenital Anomalies Of Kidney And Urinary Tract 2

  • CAKUT2

  • Ureteropelvic Junction Obstruction

  • Multicystic Renal Dysplasia, Bilateral

  • Pelviureteric Junction Obstruction

  • Pujo

  • Hydronephrosis Due To Pujo

  • Upjo

  • Mcrd

  • Congenital Anomalies Of The Kidney And Urinary Tract 2

  • Mrd

  • Pelvi-Ureteric Junction Obstruction

  • Kidney And Urinary Tract, Anomalies, Congenital, Type 2

  • Obstruction Of Pelviureteric Junction
Cholesterol Embolism

  • Atheroembolism

  • Trash Foot

  • Cholesterol Crystal Embolism

  • Purple Toe Syndrome

  • Warfarin Blue Toe Syndrome

  • Embolism, Cholesterol

  • Cholesterol Embolus Syndrome
Ureteral Disease

  • Ureteral Diseases

  • Ureteral Disorders

  • Disorder Of Ureter
Urinary Tract Obstruction

  • Obstructive Uropathy

  • Urinary Obstruction

  • Urologic Diseases
Acute Kidney Failure

  • Acute Renal Failure

  • Acute Kidney Injury

  • Renal Failure Acute

  • Kidney Failure, Acute

  • Pre-Renal Acute Kidney Injury

  • Nontraumatic Acute Kidney Injury

  • Aki - [Acute Kidney Injury]

  • Arf - [Acute Kidney Failure]

  • Acute Kidney Disease

  • Acute Kidney Impairment

  • Acute Ischaemic Renal Failure

  • Acute Hypoxic Kidney Failure

  • Acute Kidney Shutdown

  • Acute Renal Oedema

  • Acute Renal Impairment

  • Acute Kidney Collapse

  • Acute Necrotising Kidney

  • Acute Renal Suppression
Interstitial Nephritis

  • Nephritis, Interstitial

  • Renal Tubulo-Interstitial Disease

  • Nephritis Interstitial

  • Nephritis, Tubulointerstitial
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Anuria

  • Suppression Of Urinary Secretion
Kidney Papillary Necrosis

  • Necrotizing Renal Papillitis

  • Papillary Necrosis

  • Renal Papillitis Necrotizing
Hepatorenal Syndrome

  • Hepato-Renal Syndrome

  • Hepatorenal Failure

  • Hrf - [Hepatorenal Failure]

  • Hepatorenal Degeneration

  • Hepatic Renal Syndrome

  • Hepatic Renal Failure

  • Renal Hepatic Failure

  • Urohepatic Syndrome
Obstructive Nephropathy

  • Con

  • Congenital Obstructive Nephropathy

  • Nephropathy Obstructive
Inflammatory Bowel Disease 14

  • IBD14

  • Inflammatory Bowel Disease 14, Susceptibility To

  • Bowel Disease, Inflammatory, Type 14
Acute Pyelonephritis

  • Apn - [Acute Pyelonephritis]
Kidney Hypertrophy

  • Hypertrophy Of Kidney
Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

  • Catecholaminergic Polymorphic Ventricular Tachycardia 3

  • CPVT3

  • Cvpt3

  • Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3
Pyelitis
Urinary Tract Infection

  • Urinary Tract Infections

  • Uti

  • Urinary Tract Infection Nos

  • Uti - [Urinary Tract Infection]

  • Uti Nos - [Urinary Tract Infection Nos]

  • Urosepsis Nos

  • E Coli Uti

  • E Coli Urinary Tract Infection

  • Escherichia Coli Uti
Congenital Granular Cell Tumor
Hydronephrosis

  • Stricture Of Ureteropelvic Junction With Hydronephrosis

  • Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Cystic Kidney Disease

  • Renal Cyst

  • Simple Renal Cyst

  • Kidney Cysts

  • Kidney Diseases, Cystic

  • Renal Cysts

  • Kidney Cyst

  • Cystic Kidney

  • Congenital Cystic Kidney Disease

  • Cystic Kidney Diseases

  • Bosniak 1 Cyst
Fanconi Syndrome

  • Infantile Nephropathic Cystinosis

  • Adult Fanconi Syndrome

  • Congenital Fanconi Syndrome

  • De Toni-Fanconi Syndrome

  • Fanconi-De Toni Syndrome

  • Lignac-Fanconi Syndrome

  • Fanconi Renotubular Syndrome

  • Primary Fanconi Renotubular Syndrome

  • De Toni-Debre-Fanconi Syndrome

  • Adult Fanconi Anemia

  • Detoni Fanconi Syndrome

  • Fanconi-De-Toni Syndrome

  • Primary Fanconi Syndrome

  • Detoni-Debre-Fanconi Syndrome

  • Primary Fanconi Renal Syndrome

  • Fanconi Anemia

  • Cystinosis, Infantile Nephropathic

  • Fanconi-Bickel Syndrome

  • Renal Fanconi Syndrome

  • Lowe-Bickel Syndrome
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Thrombocytopenia

  • Low Platelet Count

  • Low Platelets

  • Decreased Platelets

  • Platelet Dysfunction Nos
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Vesicoureteral Reflux

  • Vesico-Ureteral Reflux
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06021 HAVCR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19510 Havcr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26004 Havcr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HAVCR1 RGD RGD:708425
Mus musculus HAVCR1 MGD MGI:2159680
Others HAVCR1 NCBI