H3-3A - H3.3 histone A Gene

Also Known as H3F3; H3-3B; H3.3A; H3F3A; BRYLIB1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3020

About H3-3A

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,061,831-226,072,019 (from NCBI)

This gene has 10 transcripts (splice variants), 185 orthologues, 20 paralogues and is associated with 73 phenotypes. Ubiquitous expression in bone marrow (RPKM 595.8), appendix (RPKM 347.4) and 25 other tissues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]

H3-3A Products (5)

mRNA Protein Name
NM_001379043.1 NP_001365972.1 histone H3.3
NM_001379045.1 NP_001365974.1 histone H3.3
NM_001379046.1 NP_001365975.1 histone H3.3
NM_001379047.1 NP_001365976.1 histone H3.3
NM_002107.7 NP_002098.1 histone H3.3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19633671 GOA
enables RNA polymerase II core promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
19633671 GOA
enables nucleosomal DNA binding IDA
IDA: Inferred from direct assay
19633671 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19494831 GOA
enables structural constituent of chromatin IDA
IDA: Inferred from direct assay
14718166 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
21636898 GOA
involved in nucleosome assembly IMP
IMP: Inferred from mutant phenotype
25615412 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
21274551 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
20110566 GOA
part of nucleosome IDA
IDA: Inferred from direct assay
14718166 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21636898 GOA
located in nucleus IMP
IMP: Inferred from mutant phenotype
34876591 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
14718166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3-3A Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

histone H3.3

  • H3 histone family member 3A

H3-3A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
H3-3A P84243 CHAF1A Homo sapiens Q13111
Anti Tag CoIP
33961781
Intra
H3-3A P84243 CHAF1A Homo sapiens Q13111
Anti Tag CoIP
23075851
Intra
H3-3A P84243 ASF1B Homo sapiens Q9NVP2
Anti Tag CoIP
23075851
Intra
H3-3A P84243 ASF1B Homo sapiens Q9NVP2
Anti Tag CoIP
33961781
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7-1
GMS
23142979
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7-1
X-Ray Diffraction
23142979
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7-1
GMS
23075851
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7-1
Ion Exchange Chrom
23075851
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7-1
X-Ray Diffraction
23075851
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7-1
Anti Tag CoIP
23075851
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
GMS
23075851
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
GMS
26167883
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
Anti Tag CoIP
23075851
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
GMS
23142979
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
Ion Exchange Chrom
23075851
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
X-Ray Diffraction
23075851
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
Anti Tag CoIP
24183680
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
X-Ray Diffraction
23142979
Intra
H3-3A P84243 H4C16 Homo sapiens P62805
X-Ray Diffraction
26167883
Cross
H3-3A P84243 Zmynd11 Mus musculus Q8R5C8
Anti Tag CoIP
24590075
Intra
H3-3A P84243 NASP Homo sapiens P49321-2
Validated Y2H
25416956
Intra
H3-3A P84243 PELP1 Homo sapiens Q8IZL8
Pull Down
20448663
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7
Validated Y2H
32296183
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7
Anti Tag CoIP
24209620
Intra
H3-3A P84243 DAXX Homo sapiens Q9UER7
Pull Down
20211137
Intra
H3-3A P84243 CBX5 Homo sapiens P45973
NMR
19834512
Intra
H3-3A P84243 CBX5 Homo sapiens P45973
Anti Tag CoIP
33961781
Intra
H3-3A P84243 CBX5 Homo sapiens P45973
Pull Down
19834512
Intra
H3-3A P84243 DNMT3A Homo sapiens Q9Y6K1
ITC
19834512
Intra
H3-3A P84243 DNMT3A Homo sapiens Q9Y6K1
Pull Down
19834512
Intra
H3-3A P84243 DNMT3A Homo sapiens Q9Y6K1
NMR
19834512
Cross
H3-3A P84243 Sfmbt Drosophila melanogaster Q9VK33
ITC
19494831
Cross: Cross-species interaction Intra: Intraspecies interaction

H3-3A Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P80177 Histone H3.3 Antibody (YA367) WB, ICC/IF, IHC-P, ChIP Human, Mouse
HY-P86113 Histone H3 (Di Methyl Lys4) Antibody (YA5805) WB, IHC-P, ICC/IF, IP, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Bryant-Li-Bhoj Neurodevelopmental Syndrome 1

  • BRYLIB1
Glioma Susceptibility 1

  • Astrocytoma

  • GLM1

  • Glioma, Susceptibility To, Somatic

  • Glioblastoma, Somatic

  • Glioma

  • Glioblastoma Multiforme

  • Oligodendroglioma

  • Glioma Somatic

  • Astrocytic Tumor

  • GLM

  • Familial Glioma Of Brain

  • Gbm

  • Glioma 1

  • Glioma, Susceptibility, Type 1

  • Cerebral Astrocytoma

  • Glioblastoma

  • Well Differentiated Oligodendroglioma
Brain Stem Glioma

  • Brainstem Glioma

  • Brainstem Neuroglial Tumor

  • Glioma Of Brainstem
Chondroblastoma

  • Chondroblastoma Of Bone
Clear Cell Chondrosarcoma

  • Chondrosarcoma, Clear Cell
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Giant Cell Glioblastoma

  • Monstrocellular Sarcoma
Gliosarcoma

  • Glioblastoma With Sarcomatous Component

  • Sarcomatous Glioblastoma
Adrenal Cortical Carcinoma

  • Adrenocortical Carcinoma

  • Adrenal Cortex Carcinoma

  • Carcinoma Of The Adrenal Cortex

  • Acc

  • Adrenocortical Cancer

  • Carcinoma Adrenocortical
Brain Stem Cancer

  • Brain Stem Neoplasms

  • Malignant Neoplasm Of Brain Stem

  • Malignant Neoplasm Of Brainstem

  • Neoplasm Of Adult Brain Stem

  • Neoplasm Of Brain Stem

  • Primary Brain Stem Neoplasm

  • Primary Brain Stem Tumor

  • Brain Stem Neoplasm

  • Brain Stem--Cancer

  • Brain Stem Neoplasms, Primary
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Bone Giant Cell Sarcoma

  • Giant Cell Sarcoma Of The Bone

  • Giant Cell Tumor Of Bone, Malignant
Malignant Giant Cell Tumor

  • Malignant Tumor, Giant Cell Type

  • Malignant Giant Cell Neoplasm
Ganglioglioma

  • Childhood Ganglioglioma

  • Adult Ganglioglioma

  • Cns Ganglioglioma

  • Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components
Adult Brain Stem Glioma

  • Adult Brainstem Neuroglial Tumor
Childhood Brain Stem Glioma

  • Pediatric Glioma Of The Brainstem
Histone Mutated Tumor

  • Histone Mutated Tumour
Spinal Cord Astrocytoma

  • Astrocytoma Of Spinal Cord

  • Spinal Astrocytoma
Anaplastic Pleomorphic Xanthoastrocytoma
Bone Benign Neoplasm
Diffuse Midline Glioma, H3 K27m-Mutant

  • Diffuse Intrinsic Pontine Glioma

  • Dipg

  • Infiltrative Brainstem Glioma
Idh-Wildtype Anaplastic Astrocytoma
Connective Tissue Benign Neoplasm

  • Soft Tissue Neoplasms

  • Mesenchymal Tissue Neoplasm

  • Neoplasm Of Soft Tissue

  • Neoplasm Of Soft Tissues

  • Soft Tissue Benign Neoplasm

  • Tumor Of The Soft Tissue

  • Soft Tissue Neoplasm
Pleomorphic Xanthoastrocytoma

  • Pxa

  • Pleomorphic Xantho-Astrocytoma
Posterior Fossa Ependymoma
Spinal Cord Glioma

  • Glial Tumor Of Spinal Cord

  • Glial Neoplasm Spinal Cord

  • Glioma Of Spinal Cord
Idh-Wildtype Glioblastoma
Telangiectatic Osteogenic Sarcoma

  • Telangiectatic Osteosarcoma
Astrocytoma, Idh-Mutant, Grade 4

  • Idh-Mutant Glioblastoma
Childhood Oligodendroglioma

  • Pediatric Oligodendroglioma

  • Oligodendroglioma, Childhood
Diffuse Astrocytoma

  • Diffuse Astrocytoma, Low Grade

  • Who Grade Ii Astrocytoma

  • Fibrillary Astrocytoma

  • Gemistocytic Astrocytoma

  • Low-Grade Diffuse Astrocytoma

  • Protoplasmic Astrocytoma
Bone Giant Cell Tumor

  • Giant Cell Tumor Of Bone

  • Osteoclastoma

  • Gct Of Bone

  • Bone Giant Cell Tumour

  • Giant Cell Myeloma

  • Giant Cell Neoplasm Of Bone

  • Giant Cell Tumour Of Bone
High Grade Ependymoma

  • Ependymal Neoplasm

  • Ependymal Tumors

  • Malignant Ependymoma

  • Ependymal Tumor

  • Anaplastic Ependymoma

  • Experimental Organism Malignant Ependymoma

  • Ependymoma Of Brain
Supratentorial Ependymoma
Ossifying Fibroma

  • Peripheral Ossifying Fibroma

  • Fibro-Osteoma

  • Fibroma Ossifying

  • Fibroma, Ossifying
Adult Oligodendroglioma

  • Adult Brain Oligodendroglioma

  • Grade Ii Adult Oligodendroglial Tumor

  • Oligodendroglioma, Adult
Adult Astrocytic Tumour

  • Adult Astrocytoma

  • Adult Astrocytic Tumors
Gliomatosis Cerebri

  • Astrocytosis Cerebri

  • Neoplasms, Neuroepithelial
Spinal Cancer

  • Spinal Cord Neoplasm

  • Spinal Cord Neoplasms

  • Spinal Neoplasms

  • Intraspinal Tumor

  • Malignant Tumor Of The Spinal Cord

  • Spinal Cord Cancer

  • Spinal Neoplasm

  • Tumor Of The Spinal Cord

  • Tumors Spinal Cord

  • Intraspinal Neoplasm

  • Spinal Cord--Cancer
Benign Giant Cell Tumor

  • Giant Cell Tumors
Hutchinson-Gilford Progeria Syndrome

  • Progeria

  • HGPS

  • Hutchinson-Gilford Syndrome

  • Hutchinson-Gilford Progeria

  • Hutchinson Gilford Syndrome

  • Hutchinson Gilford Progeria Syndrome

  • Hutchinson-Gilford Disease

  • Progeria Of Childhood

  • Hutchinson-Gilford-Progeria Syndrome
Dysembryoplastic Neuroepithelial Tumor

  • Dysembryoplastic Neuroepithelial Tumour

  • Dysembryoplastic Neuroepithelial Neoplasm

  • Dnet
Low Grade Glioma

  • Benign Glioma
Chondroblastic Osteosarcoma

  • Chondrosarcomatous Osteogenic Sarcoma
Diffuse Large B-Cell Lymphoma

  • Dlbcl

  • Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

  • Large B-Cell Diffuse Lymphoma

  • Lymphoma, Large B-Cell, Diffuse

  • Dlbcl - [Diffuse Large B-Cell Lymphoma]

  • Diffuse Large Beta Cell Lymphoma
Cerebral Ventricle Cancer

  • Cerebral Ventricle Neoplasms

  • Cerebral Ventricle Neoplasm

  • Intraventricular Tumor Of Brain
Giant Cell Reparative Granuloma

  • Central Giant Cell Granuloma

  • Central Giant Cell Reparative Granuloma Of Jaw

  • Central Giant Cell Granuloma

  • Granuloma, Giant Cell

  • Granuloma, Giant Cell Reparative

  • Giant Cell Lesion Of Small Bones

  • Giant Cell Granuloma, Nos
Central Nervous System Benign Neoplasm

  • Benign Neoplasm Of The Central Nervous System
Supratentorial Cancer

  • Supratentorial Neoplasms

  • Brain Neoplasm, Supratentorial

  • Malignant Supratentorial Tumor

  • Cancer, Supratentorial
Periosteal Osteogenic Sarcoma

  • Periosteal Osteosarcoma

  • Parosteal Osteosarcoma
Pilocytic Astrocytoma Of Cerebellum

  • Cerebellar Pilocytic Astrocytoma
Cerebrum Cancer

  • Cerebral Cancer

  • Neoplasm Of Cerebrum

  • Tumor Of Cerebrum

  • Malignant Neoplasm Of Cerebrum
Fibrillary Astrocytoma

  • Fibrillary Astrocytic Tumors

  • Diffuse Astrocytoma

  • Gemistocytic Astrocytoma

  • Protoplasmic Astrocytoma
Oculoectodermal Syndrome

  • Aplasia Cutis Congenita With Epibulbar Dermoids

  • Toriello-Lacassie-Droste Syndrome

  • Oculoectodermal Syndrome, Somatic

  • OES

  • Aplasia Cutis Congenita-Epibulbar Dermoids Syndrome

  • Oculo-Ectodermal Syndrome

  • Toriello Lacassie Droste Syndrome
Juvenile Pilocytic Astrocytoma
Pilomyxoid Astrocytoma
Obstructive Hydrocephalus
Spinal Cord Disease

  • Spinal Cord Diseases

  • Myelopathy

  • Bone Marrow Diseases
Childhood Astrocytic Tumor

  • Juvenile Astrocytoma

  • Pediatric Astrocytoma
Cerebellar Astrocytoma

  • Astrocytoma Of Cerebellum
Alpha Thalassemia-X-Linked Intellectual Disability Syndrome

  • Atr-X Syndrome

  • Atr, Nondeletion Type

  • Alpha-Thalassemia X-Linked Intellectual Disability Syndrome

  • Atrx Syndrome

  • Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type

  • Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked

  • X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome

  • Xlmr Hypotonic Face Syndrome

  • Alpha Thalassemia X-Linked Intellectual Disability Syndrome

  • Alpha Thalassemia X-Linked Mental Retardation Syndrome

  • Alpha Thalassemia/Mental Retardation, X-Linked

  • Alpha-Thalassemia X-Linked Mental Retardation Syndrome

  • Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type

  • X-Linked Alpha-Thalassemia/Mental Retardation Syndrome

  • Xlmr-Hypotonic Face Syndrome

  • Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome

  • Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked
Multiple Enchondromatosis, Maffucci Type

  • Maffucci Syndrome

  • Chondrodysplasia With Hemangioma

  • Chondroplasia Angiomatosis

  • Enchondromatosis With Hemangiomata

  • Hemangiomatosis Chondrodystrophica

  • Kast Syndrome

  • Multiple Angiomas And Endochondromas

  • Dyschondrodysplasia With Hemangiomas

  • Enchondromatosis Type Ii

  • Enchondromatosis With Multiple Cavernous Hemangiomas

  • Dyschondroplasia And Cavernous Hemangioma

  • Hemangiomata With Dyschondroplasia
Pilocytic Astrocytoma

  • Juvenile Pilocytic Astrocytoma

  • Grade I Astrocytic Tumor

  • Piloid Astrocytoma
Atypical Teratoid Rhabdoid Tumor

  • Rhabdoid Tumor Predisposition Syndrome

  • Rtps

  • Atypical Teratoid/Rhabdoid Tumor

  • Rhabdoid Predisposition Syndrome

  • Familial Posterior Fossa Brain Tumor Of Infancy

  • Familial Rhabdoid Tumor

  • At/Rt

  • Atypical Teratoid Rhabdoid Tumour

  • Atypical Teratoid/Rhabdoid Tumour

  • Rhabdoid Tumor Of The Cns

  • Rhabdoid Tumour Of The Cns

  • Familial Posterior Fossa Brain Tumor Syndrome

  • Hereditary Swi/Snf Deficiency Syndrome

  • Atrt
Anaplastic Ependymoma

  • Ependymoma, Anaplastic

  • Undifferentiated Ependymoma
Anaplastic Oligodendroglioma
Infratentorial Cancer

  • Infratentorial Neoplasms

  • Brain Neoplasm, Infratentorial

  • Malignant Infratentorial Tumors
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Brain Glioma

  • Lower Grade Glioma

  • Intracranial Glioma

  • Glioma Nos
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Alpha-Thalassemia

  • Alpha Thalassemia

  • Alpha Thalassaemia

  • Alpha Plus Thalassemia

  • Thalassemia, Alpha-

  • Thalassemias, Alpha-

  • A-Thalassemia

  • Α-Thalassemia

  • A-THAL

  • Thalassemia

  • Alpha Thalassaemia Syndrome
Bone Osteosarcoma

  • Osteosarcoma Of Bone

  • Primary Osteosarcoma Of Bone
Intracranial Cavernous Angioma

  • Intracranial Cavernoma

  • Intracranial Cavernous Hemangioma
Intracranial Structure Hemangioma

  • Angioma Of Intracranial Structure

  • Hemangioma Of Intracranial Structure

  • Hemangioma Of Intracranial Structures
Colon Leiomyoma

  • Colonic Leiomyoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05962 H3-3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05961 H3-3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus H3-3A MGD MGI:1097686
Rattus norvegicus H3-3A RGD RGD:2319910