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  2. H3-3A - H3.3 histone A Gene

H3-3A - H3.3 histone A Gene

Homo sapiens

Also known as H3F3; H3-3B; H3.3A; H3F3A; BRYLIB1

Gene ID: 3020 | Gene type: protein coding

About H3-3A

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,061,831-226,072,019 (from NCBI)

This gene has 10 transcripts (splice variants), 185 orthologues, 20 paralogues and is associated with 73 phenotypes. Ubiquitous expression in bone marrow (RPKM 595.8), appendix (RPKM 347.4) and 25 other tissues.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. [provided by RefSeq, Jul 2008]

H3-3A Products(5)

mRNA Protein Name
NM_001379043.1 NP_001365972.1 histone H3.3
NM_001379045.1 NP_001365974.1 histone H3.3
NM_001379046.1 NP_001365975.1 histone H3.3
NM_001379047.1 NP_001365976.1 histone H3.3
NM_002107.7 NP_002098.1 histone H3.3

H3-3A Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

histone H3.3

H3 histone family member 3A

Related Diseases

Diseases Alias
Bryant-Li-Bhoj Neurodevelopmental Syndrome 1

BRYLIB1

Glioma Susceptibility 1

Astrocytoma

GLM1

Glioma, Susceptibility To, Somatic

Glioblastoma, Somatic

Glioma

Glioblastoma Multiforme

Oligodendroglioma

Glioma Somatic

Astrocytic Tumor

GLM

Familial Glioma Of Brain

Gbm

Glioma 1

Glioma, Susceptibility, Type 1

Cerebral Astrocytoma

Glioblastoma

Well Differentiated Oligodendroglioma

Brain Stem Glioma

Brainstem Glioma

Brainstem Neuroglial Tumor

Glioma Of Brainstem

Chondroblastoma

Chondroblastoma Of Bone

Clear Cell Chondrosarcoma

Chondrosarcoma, Clear Cell

Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary

Giant Cell Glioblastoma

Monstrocellular Sarcoma

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Adrenal Cortical Carcinoma

Adrenocortical Carcinoma

Adrenal Cortex Carcinoma

Carcinoma Of The Adrenal Cortex

Acc

Adrenocortical Cancer

Carcinoma Adrenocortical

Brain Stem Cancer

Brain Stem Neoplasms

Malignant Neoplasm Of Brain Stem

Malignant Neoplasm Of Brainstem

Neoplasm Of Adult Brain Stem

Neoplasm Of Brain Stem

Primary Brain Stem Neoplasm

Primary Brain Stem Tumor

Brain Stem Neoplasm

Brain Stem--Cancer

Brain Stem Neoplasms, Primary

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Bone Giant Cell Sarcoma

Giant Cell Sarcoma Of The Bone

Giant Cell Tumor Of Bone, Malignant

Malignant Giant Cell Tumor

Malignant Tumor, Giant Cell Type

Malignant Giant Cell Neoplasm

Ganglioglioma

Childhood Ganglioglioma

Adult Ganglioglioma

Cns Ganglioglioma

Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components

Adult Brain Stem Glioma

Adult Brainstem Neuroglial Tumor

Childhood Brain Stem Glioma

Pediatric Glioma Of The Brainstem

Histone Mutated Tumor

Histone Mutated Tumour

Spinal Cord Astrocytoma

Astrocytoma Of Spinal Cord

Spinal Astrocytoma

Anaplastic Pleomorphic Xanthoastrocytoma
Bone Benign Neoplasm
Diffuse Midline Glioma, H3 K27m-Mutant

Diffuse Intrinsic Pontine Glioma

Dipg

Infiltrative Brainstem Glioma

Idh-Wildtype Anaplastic Astrocytoma
Connective Tissue Benign Neoplasm

Soft Tissue Neoplasms

Mesenchymal Tissue Neoplasm

Neoplasm Of Soft Tissue

Neoplasm Of Soft Tissues

Soft Tissue Benign Neoplasm

Tumor Of The Soft Tissue

Soft Tissue Neoplasm

Pleomorphic Xanthoastrocytoma

Pxa

Pleomorphic Xantho-Astrocytoma

Posterior Fossa Ependymoma
Spinal Cord Glioma

Glial Tumor Of Spinal Cord

Glial Neoplasm Spinal Cord

Glioma Of Spinal Cord

Idh-Wildtype Glioblastoma
Telangiectatic Osteogenic Sarcoma

Telangiectatic Osteosarcoma

Astrocytoma, Idh-Mutant, Grade 4

Idh-Mutant Glioblastoma

Childhood Oligodendroglioma

Pediatric Oligodendroglioma

Oligodendroglioma, Childhood

Diffuse Astrocytoma

Diffuse Astrocytoma, Low Grade

Who Grade Ii Astrocytoma

Fibrillary Astrocytoma

Gemistocytic Astrocytoma

Low-Grade Diffuse Astrocytoma

Protoplasmic Astrocytoma

Bone Giant Cell Tumor

Giant Cell Tumor Of Bone

Osteoclastoma

Gct Of Bone

Bone Giant Cell Tumour

Giant Cell Myeloma

Giant Cell Neoplasm Of Bone

Giant Cell Tumour Of Bone

High Grade Ependymoma

Ependymal Neoplasm

Ependymal Tumors

Malignant Ependymoma

Ependymal Tumor

Anaplastic Ependymoma

Experimental Organism Malignant Ependymoma

Ependymoma Of Brain

Supratentorial Ependymoma
Ossifying Fibroma

Peripheral Ossifying Fibroma

Fibro-Osteoma

Fibroma Ossifying

Fibroma, Ossifying

Adult Oligodendroglioma

Adult Brain Oligodendroglioma

Grade Ii Adult Oligodendroglial Tumor

Oligodendroglioma, Adult

Adult Astrocytic Tumour

Adult Astrocytoma

Adult Astrocytic Tumors

Gliomatosis Cerebri

Astrocytosis Cerebri

Neoplasms, Neuroepithelial

Spinal Cancer

Spinal Cord Neoplasm

Spinal Cord Neoplasms

Spinal Neoplasms

Intraspinal Tumor

Malignant Tumor Of The Spinal Cord

Spinal Cord Cancer

Spinal Neoplasm

Tumor Of The Spinal Cord

Tumors Spinal Cord

Intraspinal Neoplasm

Spinal Cord--Cancer

Benign Giant Cell Tumor

Giant Cell Tumors

Hutchinson-Gilford Progeria Syndrome

Progeria

HGPS

Hutchinson-Gilford Syndrome

Hutchinson-Gilford Progeria

Hutchinson Gilford Syndrome

Hutchinson Gilford Progeria Syndrome

Hutchinson-Gilford Disease

Progeria Of Childhood

Hutchinson-Gilford-Progeria Syndrome

Dysembryoplastic Neuroepithelial Tumor

Dysembryoplastic Neuroepithelial Tumour

Dysembryoplastic Neuroepithelial Neoplasm

Dnet

Low Grade Glioma

Benign Glioma

Chondroblastic Osteosarcoma

Chondrosarcomatous Osteogenic Sarcoma

Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma

Cerebral Ventricle Cancer

Cerebral Ventricle Neoplasms

Cerebral Ventricle Neoplasm

Intraventricular Tumor Of Brain

Giant Cell Reparative Granuloma

Central Giant Cell Granuloma

Central Giant Cell Reparative Granuloma Of Jaw

Central Giant Cell Granuloma

Granuloma, Giant Cell

Granuloma, Giant Cell Reparative

Giant Cell Lesion Of Small Bones

Giant Cell Granuloma, Nos

Central Nervous System Benign Neoplasm

Benign Neoplasm Of The Central Nervous System

Supratentorial Cancer

Supratentorial Neoplasms

Brain Neoplasm, Supratentorial

Malignant Supratentorial Tumor

Cancer, Supratentorial

Periosteal Osteogenic Sarcoma

Periosteal Osteosarcoma

Parosteal Osteosarcoma

Pilocytic Astrocytoma Of Cerebellum

Cerebellar Pilocytic Astrocytoma

Cerebrum Cancer

Cerebral Cancer

Neoplasm Of Cerebrum

Tumor Of Cerebrum

Malignant Neoplasm Of Cerebrum

Fibrillary Astrocytoma

Fibrillary Astrocytic Tumors

Diffuse Astrocytoma

Gemistocytic Astrocytoma

Protoplasmic Astrocytoma

Oculoectodermal Syndrome

Aplasia Cutis Congenita With Epibulbar Dermoids

Toriello-Lacassie-Droste Syndrome

Oculoectodermal Syndrome, Somatic

OES

Aplasia Cutis Congenita-Epibulbar Dermoids Syndrome

Oculo-Ectodermal Syndrome

Toriello Lacassie Droste Syndrome

Juvenile Pilocytic Astrocytoma
Pilomyxoid Astrocytoma
Obstructive Hydrocephalus
Spinal Cord Disease

Spinal Cord Diseases

Myelopathy

Bone Marrow Diseases

Childhood Astrocytic Tumor

Juvenile Astrocytoma

Pediatric Astrocytoma

Cerebellar Astrocytoma

Astrocytoma Of Cerebellum

Alpha Thalassemia-X-Linked Intellectual Disability Syndrome

Atr-X Syndrome

Atr, Nondeletion Type

Alpha-Thalassemia X-Linked Intellectual Disability Syndrome

Atrx Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome Nondeletion Type

Alpha Thalassemia Intellectual Disability Syndrome, Nondeletion Type, X-Linked

X-Linked Alpha-Thalassemia/Intellectual Disability Syndrome

Xlmr Hypotonic Face Syndrome

Alpha Thalassemia X-Linked Intellectual Disability Syndrome

Alpha Thalassemia X-Linked Mental Retardation Syndrome

Alpha Thalassemia/Mental Retardation, X-Linked

Alpha-Thalassemia X-Linked Mental Retardation Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type

X-Linked Alpha-Thalassemia/Mental Retardation Syndrome

Xlmr-Hypotonic Face Syndrome

Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Nondeletion Type, X-Linked

Multiple Enchondromatosis, Maffucci Type

Maffucci Syndrome

Chondrodysplasia With Hemangioma

Chondroplasia Angiomatosis

Enchondromatosis With Hemangiomata

Hemangiomatosis Chondrodystrophica

Kast Syndrome

Multiple Angiomas And Endochondromas

Dyschondrodysplasia With Hemangiomas

Enchondromatosis Type Ii

Enchondromatosis With Multiple Cavernous Hemangiomas

Dyschondroplasia And Cavernous Hemangioma

Hemangiomata With Dyschondroplasia

Pilocytic Astrocytoma

Juvenile Pilocytic Astrocytoma

Grade I Astrocytic Tumor

Piloid Astrocytoma

Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome

Rtps

Atypical Teratoid/Rhabdoid Tumor

Rhabdoid Predisposition Syndrome

Familial Posterior Fossa Brain Tumor Of Infancy

Familial Rhabdoid Tumor

At/Rt

Atypical Teratoid Rhabdoid Tumour

Atypical Teratoid/Rhabdoid Tumour

Rhabdoid Tumor Of The Cns

Rhabdoid Tumour Of The Cns

Familial Posterior Fossa Brain Tumor Syndrome

Hereditary Swi/Snf Deficiency Syndrome

Atrt

Anaplastic Ependymoma

Ependymoma, Anaplastic

Undifferentiated Ependymoma

Anaplastic Oligodendroglioma
Infratentorial Cancer

Infratentorial Neoplasms

Brain Neoplasm, Infratentorial

Malignant Infratentorial Tumors

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Brain Glioma

Lower Grade Glioma

Intracranial Glioma

Glioma Nos

Anaplastic Astrocytoma

Grade Iii Astrocytoma

Astrocytoma, Anaplastic

Grade Iii Astrocytic Tumor

Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Intracranial Cavernous Angioma

Intracranial Cavernoma

Intracranial Cavernous Hemangioma

Intracranial Structure Hemangioma

Angioma Of Intracranial Structure

Hemangioma Of Intracranial Structure

Hemangioma Of Intracranial Structures

Colon Leiomyoma

Colonic Leiomyoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus H3-3A MGD MGI:1097686
Rattus norvegicus H3-3A RGD RGD:2319910