PELP1 - proline, glutamate and leucine rich protein 1 Gene

Also Known as MNAR; P160

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27043

About PELP1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,669,774-4,704,137 (from NCBI)

This gene has 15 transcripts (splice variants) and 110 orthologues. Ubiquitous expression in testis (RPKM 17.1), brain (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a transcription factor which coactivates transcription of Estrogen receptor responsive genes and corepresses genes activated by Other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the Estrogen receptor family. This gene may be involved in the progression of several types of Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

PELP1 Products (2)

mRNA Protein Name
NM_001278241.2 NP_001265170.1 proline-, glutamic acid- and leucine-rich protein 1 isoform 2
NM_014389.3 NP_055204.4 proline-, glutamic acid- and leucine-rich protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables SUMO binding IMP
IMP: Inferred from mutant phenotype
27814492 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
17505058 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to estrogen stimulus IDA
IDA: Inferred from direct assay
17505058 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17505058 GOA
Cellular Component GO Annotation Evidence References Source
part of MLL1 complex IDA
IDA: Inferred from direct assay
15960975 GOA
located in euchromatin IDA
IDA: Inferred from direct assay
17505058 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27814492 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PELP1 Protein Structure

RIX1

RIX1: rRNA processing/ribosome biogenesis (73 - 224)

NUC202

NUC202: NUC202 domain (423 - 488)

NUC202

NUC202: NUC202 domain (569 - 639)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1130 a.a.
Protein Preferred Names Protein Names

proline-, glutamic acid- and leucine-rich protein 1

  • modulator of non-genomic activity of estrogen receptor

PELP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PELP1 Q8IZL8 MDN1 Homo sapiens Q9NU22
Anti Tag CoIP
21326211
Intra
PELP1 Q8IZL8 MDN1 Homo sapiens Q9NU22
Pull Down
21326211
Intra
PELP1 Q8IZL8 H3-3A Homo sapiens P84243
Anti Bait CoIP
20448663
Intra
PELP1 Q8IZL8 H3-3A Homo sapiens P84243
Pull Down
20448663
Intra
PELP1 Q8IZL8 TEX10 Homo sapiens Q9NXF1
Crosslink
36351913
Intra
PELP1 Q8IZL8 TEX10 Homo sapiens Q9NXF1
Anti Tag CoIP
36351913
Intra
PELP1 Q8IZL8 SENP3 Homo sapiens Q9H4L4
IF
21326211
Intra
PELP1 Q8IZL8 SENP3 Homo sapiens Q9H4L4
Anti Tag CoIP
36351913
Intra
PELP1 Q8IZL8 SENP3 Homo sapiens Q9H4L4
Crosslink
36351913
Intra
PELP1 Q8IZL8 NFKB1 Homo sapiens P19838
TAP
20195357
Intra
PELP1 Q8IZL8 NFKB1 Homo sapiens P19838
Display Tech
20195357
Intra
PELP1 Q8IZL8 SUMO2 Homo sapiens P61956
Y2H Pooling
16169070
Intra
PELP1 Q8IZL8 KDM1A Homo sapiens O60341
Pull Down
20448663
Intra
PELP1 Q8IZL8 KDM1A Homo sapiens O60341
Anti Bait CoIP
20448663
Intra
PELP1 Q8IZL8 KDM1A Homo sapiens O60341
Anti Tag CoIP
20448663
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Tag CoIP
21326211
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Tag CoIP
36351913
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
3D-EM
36351913
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Bait CoIP
36351913
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Anti Bait CoIP
21326211
Intra
PELP1 Q8IZL8 WDR18 Homo sapiens Q9BV38
Crosslink
36351913
Intra
PELP1 Q8IZL8 NPM1 Homo sapiens P06748
Anti Bait CoIP
21326211
Cross: Cross-species interaction Intra: Intraspecies interaction

PELP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83217 PELP1 Antibody (YA2962) WB, IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Brain Oligodendroglioma

  • Oligodendroglioma Of Brain
Brain Ependymoma

  • Ependymal Tumor Of Brain

  • Ependymoma Of Brain
Amelogenesis Imperfecta, Type Ig

  • Enamel-Renal Syndrome

  • Ers

  • Amelogenesis Imperfecta Type 1g

  • AI1G

  • Enamel-Renal-Gingival Syndrome

  • Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

  • Aigfs

  • Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

  • Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

  • Amelogenesis Imperfecta Type Ig

  • Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

  • Amelogenesis Imperfecta 1g

  • Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

  • Amelogenesis Imperfecta Nephrocalcinosis
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Teeth Hard Tissue Disease
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169903 SMIP34 Inducer 90.0% Unkown
HY-159613 PELP1-IN-1 99.28% Unkown
HY-RS10324 PELP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179433 PROTAC AR Degrader-12 / Unkown
HY-RS29513 Pelp1 Mouse Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PELP1 VGNC VGNC:64111
Mus musculus PELP1 MGD MGI:1922523
Macaca mulatta PELP1 VGNC VGNC:75894
Rattus norvegicus PELP1 RGD RGD:1306320
Canis familiaris PELP1 VGNC VGNC:44417
Bos taurus PELP1 VGNC VGNC:32744
Others PELP1 NCBI