MDN1 - midasin AAA ATPase 1 Gene

Also Known as Rea1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23195

About MDN1

Cytogenetic location: 6q15 Genomic coordinates (GRCh38): 6:89,642,498-89,819,794 (from NCBI)

This gene has 28 transcripts (splice variants), 1 gene allele, 209 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 5.6), testis (RPKM 4.9) and 25 other tissues.

Summary

Predicted to enable ATP binding activity. Involved in ribosomal large subunit assembly. Located in cytosol; intermediate filament cytoskeleton; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

MDN1 Products (1)

mRNA Protein Name
NM_014611.3 NP_055426.1 midasin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21326211 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosomal large subunit assembly IDA
IDA: Inferred from direct assay
27814492 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
27814492 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MDN1 Protein Structure

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (325 - 452)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (672 - 768)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (816 - 902)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (1079 - 1215)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (1385 - 1540)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (1749 - 1888)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (2062 - 2106)

AAA_5

AAA_5: AAA domain (dynein-related subfamily) (2219 - 2300)

  • 0
  • 900
  • 1800
  • 2700
  • 3600
  • 4500
  • 5400
  • 5596 a.a.
Protein Preferred Names Protein Names

midasin

  • MDN1, midasin homolog

MDN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MDN1 Q9NU22 PELP1 Homo sapiens Q8IZL8
Anti Bait CoIP
21326211
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Apical Periodontitis

  • Acute Apical Periodontitis Of Pulpal Origin

  • Acute Apical Periodontitis Nos

  • Aap - [Acute Apical Periodontitis]
Ewing Sarcoma Of Bone

  • Ewing'S Sarcoma Of Bone

  • Bone Ewing Sarcoma

  • Bone Ewing'S Sarcoma

  • Bone Localized Ewing Sarcoma

  • Bone Localized Ewing'S Sarcoma

  • Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor

  • Localized Skeletal Ewing'S Sarcoma

  • Localized Bone Ewing Sarcoma
Plasmodium Ovale Malaria

  • Ovale Malaria

  • Malariaby Plasmodium Ovale
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100816 Rbin-1 Inhibitor 99.85% Unkown
HY-100817 Rbin-2 Inhibitor 98.0% Unkown
HY-RS08268 MDN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20772 Mdn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27286 Mdn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MDN1 MGD MGI:1926159
Macaca mulatta MDN1 VGNC VGNC:74530
Bos taurus MDN1 VGNC VGNC:31338
Canis familiaris MDN1 VGNC VGNC:43108
Rattus norvegicus MDN1 RGD RGD:1306394
Felis catus MDN1 VGNC VGNC:102458
Others MDN1 NCBI