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SNRPG - small nuclear ribonucleoprotein polypeptide G Gene

Also Known as SMG; Sm-G

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6637

About SNRPG

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:70,281,362-70,293,740 (from NCBI)

This gene has 9 transcripts (splice variants), 181 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 14.7), appendix (RPKM 13.1) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

SNRPG Products (7)

mRNA	Protein	Name
NM_001317165.2	NP_001304094.1	small nuclear ribonucleoprotein G isoform b
NM_001317166.2	NP_001304095.1	small nuclear ribonucleoprotein G isoform c
NM_001317167.1	NP_001304096.1	small nuclear ribonucleoprotein G isoform d
NM_001317168.1	NP_001304097.1	small nuclear ribonucleoprotein G isoform e
NM_001317169.2	NP_001304098.1	small nuclear ribonucleoprotein G isoform e
NM_001317171.2	NP_001304100.1	small nuclear ribonucleoprotein G isoform f
NM_003096.4	NP_003087.1	small nuclear ribonucleoprotein G isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9417867	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U4 snRNP	IDA IDA: Inferred from direct assay	21516107	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of U7 snRNP	IDA IDA: Inferred from direct assay	11574479	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of methylosome	IDA IDA: Inferred from direct assay	18984161	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPG Protein Structure

LSM

0
76 a.a.

Protein Preferred Names	Protein Names
small nuclear ribonucleoprotein G	sm protein G

SNRPG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	SNRPG	P62308	NFATC2IP	Homo sapiens	Q8NCF5-2	Y2H Pooling	32814053
Intra	SNRPG	P62308	NFATC2IP	Homo sapiens	Q8NCF5-2	Validated Y2H	32814053
Intra	SNRPG	P62308	NFATC2IP	Homo sapiens	Q8NCF5-2	Y2H Array	32814053
Intra	SNRPG	P62308	SF3A2	Homo sapiens	Q15428	Affinity Chrom	17332742
Intra	SNRPG	P62308	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPG	P62308	SNRPE	Homo sapiens	P62304	Y2H Array	32296183
Intra	SNRPG	P62308	SNRPE	Homo sapiens	P62304	Anti Tag CoIP	33961781
Intra	SNRPG	P62308	SNRPE	Homo sapiens	P62304	Y2H Prey Pooling	32296183
Intra	SNRPG	P62308	SNRPE	Homo sapiens	P62304	Crosslink	30021884
Intra	SNRPG	P62308	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	33961781
Intra	SNRPG	P62308	SNRPF	Homo sapiens	P62306	Y2H	22365833
Intra	SNRPG	P62308	TFF2	Homo sapiens	Q03403	Validated Y2H	32814053
Intra	SNRPG	P62308	TFF2	Homo sapiens	Q03403	Y2H Array	32814053
Intra	SNRPG	P62308	TFF2	Homo sapiens	Q03403	Y2H Pooling	32814053
Intra	SNRPG	P62308	TACC1	Homo sapiens	O75410-1	Pull Down	12165861
Intra	SNRPG	P62308	TACC1	Homo sapiens	O75410-1	Y2H	12165861
Intra	SNRPG	P62308	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	25416956
Intra	SNRPG	P62308	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	33961781
Intra	SNRPG	P62308	CLNS1A	Homo sapiens	P54105	Y2H Prey Pooling	32296183
Intra	SNRPG	P62308	CLNS1A	Homo sapiens	P54105	Validated Y2H	25416956
Intra	SNRPG	P62308	CLNS1A	Homo sapiens	P54105	Y2H Array	25416956
Intra	SNRPG	P62308	CLNS1A	Homo sapiens	P54105	Y2H Array	32296183
Intra	SNRPG	P62308	TCL1B	Homo sapiens	O95988	Y2H Prey Pooling	32296183
Intra	SNRPG	P62308	TCL1B	Homo sapiens	O95988	Y2H Array	32296183
Intra	SNRPG	P62308	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	SNRPG	P62308	FHL3	Homo sapiens	Q13643	Validated Y2H	32296183
Intra	SNRPG	P62308	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	SNRPG	P62308	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	25416956
Intra	SNRPG	P62308	DDIT4L	Homo sapiens	Q96D03	Y2H Pooling	16189514
Intra	SNRPG	P62308	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	25416956
Intra	SNRPG	P62308	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	SNRPG	P62308	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	25416956
Intra	SNRPG	P62308	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	SNRPG	P62308	DDIT4L	Homo sapiens	Q96D03	Y2H Array	25416956
Intra	SNRPG	P62308	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	SNRPG	P62308	GEMIN6	Homo sapiens	Q8WXD5	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS13510	SNRPG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22811	Snrpg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29326	Snrpg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SNRPG	VGNC	VGNC:54547
Mus musculus	SNRPG	MGD	MGI:1915261
Rattus norvegicus	SNRPG	RGD	RGD:1584713
Others	SNRPG	NCBI