HNMPA-(AM)3
Based on 1 Customer Validation
HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively).
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- Reinheit: 98.04%
- CAS. Nr.: 120944-03-8
- Formel: C20H23O10P
- Molecular Weight:454.36
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Biologische Aktivität
IC50: 14.2 μM (ecdysteroid production), 14.2 μM (mosquito insulin receptor), 200 μM (mammalian insulin receptor))[2]
Chemical Information
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CAS. Nr. 120944-03-8
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Appearance Oil
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Molecular Weight 454.36
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Formel C20H23O10P
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Color Off-white to light yellow
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SMILES
CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (110.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Riehle MA, et al. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 1999 Oct;29(10):855-60. [Content Brief]
[2]. Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca2+/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2009 mL | 11.0045 mL | 22.0090 mL | 55.0225 mL |
| 5 mM | 0.4402 mL | 2.2009 mL | 4.4018 mL | 11.0045 mL | |
| 10 mM | 0.2201 mL | 1.1004 mL | 2.2009 mL | 5.5022 mL | |
| 15 mM | 0.1467 mL | 0.7336 mL | 1.4673 mL | 3.6682 mL | |
| 20 mM | 0.1100 mL | 0.5502 mL | 1.1004 mL | 2.7511 mL | |
| 25 mM | 0.0880 mL | 0.4402 mL | 0.8804 mL | 2.2009 mL | |
| 30 mM | 0.0734 mL | 0.3668 mL | 0.7336 mL | 1.8341 mL | |
| 40 mM | 0.0550 mL | 0.2751 mL | 0.5502 mL | 1.3756 mL | |
| 50 mM | 0.0440 mL | 0.2201 mL | 0.4402 mL | 1.1004 mL | |
| 60 mM | 0.0367 mL | 0.1834 mL | 0.3668 mL | 0.9170 mL | |
| 80 mM | 0.0275 mL | 0.1376 mL | 0.2751 mL | 0.6878 mL | |
| 100 mM | 0.0220 mL | 0.1100 mL | 0.2201 mL | 0.5502 mL |
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