120944-03-8
Chemical Structure
HNMPA-(AM)3
- CAS No.: 120944-03-8
- Formula:C20H23O10P
- Molecular Weight:454.36
IUPAC Name: ((((acetoxymethoxy)(naphthalen-2-yl)methyl)phosphoryl)bis(oxy))bis(methylene) diacetate
InChIKey: UQODAZKXEREJLZ-UHFFFAOYSA-N
SMILES: CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O
Biological Activity: HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HNMPA-(AM)3 | 98.04% | HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively). | ||||||||||||||||||||
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References
- [1]. Riehle MA, et al. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 1999 Oct;29(10):855-60. [Content Brief]
- [2]. Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca2+/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101. [Content Brief]
