HNMPA-(AM)3
Based on 1 Customer Validation
HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively).
For research use only. We do not sell to patients.
- Purity: 98.04%
- CAS No.: 120944-03-8
- Formula: C20H23O10P
- Molecular Weight:454.36
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 14.2 μM (ecdysteroid production), 14.2 μM (mosquito insulin receptor), 200 μM (mammalian insulin receptor))[2]
Chemical Information
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CAS No. 120944-03-8
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Appearance Oil
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Molecular Weight 454.36
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Formula C20H23O10P
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Color Off-white to light yellow
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SMILES
CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Riehle MA, et al. Insulin stimulates ecdysteroid production through a conserved signaling cascade in the mosquito Aedes aegypti. Insect Biochem Mol Biol. 1999 Oct;29(10):855-60. [Content Brief]
[2]. Gu SH, et al. PTTH-stimulated ERK phosphorylation in prothoracic glands of the silkworm, Bombyx mori: role of Ca2+/calmodulin and receptor tyrosine kinase. J Insect Physiol. 2010;56(1):93-101. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HNMPA-(AM)3 Related Classifications
HY-124097 Related Classifications
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