2. Protein Tyrosine Kinase/RTK
  3. Insulin Receptor
  4. HNMPA-(AM)3

HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively).

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HNMPA-(AM)3 Chemical Structure

HNMPA-(AM)3 Chemical Structure

CAS No. : 120944-03-8

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Based on 1 publication(s) in Google Scholar

HNMPA-(AM)3 Related Antibodies

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Description

HNMPA-(AM)3 is a cell-permeable and selective insulin receptor tyrosine kinase inhibitor analog of HNMPA. HNMPA-(AM)3 greatly inhibits the ability of prothoracicotropic hormone (PTTH) to activate ERK phosphorylation and stimulate ecdysteroidogenesis. HNMPA-(AM)3 is also effective in inhibiting ecdysteroid production (IC50=14.2 μM) and insulin receptor activity (IC50 is 14.2 μM and 200 μM in mosquitoes and mammals, respectively)[1][2].

IC50 & Target

IC50: 14.2 μM (ecdysteroid production), 14.2 μM (mosquito insulin receptor), 200 μM (mammalian insulin receptor))[2]
Molecular Weight

454.36

Formula

C20H23O10P
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

CC(OCOC(C1=CC2=CC=CC=C2C=C1)P(OCOC(C)=O)(OCOC(C)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (220.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2009 mL 11.0045 mL 22.0090 mL
5 mM 0.4402 mL 2.2009 mL 4.4018 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2009 mL 11.0045 mL 22.0090 mL 55.0225 mL
5 mM 0.4402 mL 2.2009 mL 4.4018 mL 11.0045 mL
10 mM 0.2201 mL 1.1004 mL 2.2009 mL 5.5022 mL
15 mM 0.1467 mL 0.7336 mL 1.4673 mL 3.6682 mL
20 mM 0.1100 mL 0.5502 mL 1.1004 mL 2.7511 mL
25 mM 0.0880 mL 0.4402 mL 0.8804 mL 2.2009 mL
30 mM 0.0734 mL 0.3668 mL 0.7336 mL 1.8341 mL
40 mM 0.0550 mL 0.2751 mL 0.5502 mL 1.3756 mL
50 mM 0.0440 mL 0.2201 mL 0.4402 mL 1.1004 mL
60 mM 0.0367 mL 0.1834 mL 0.3668 mL 0.9170 mL
80 mM 0.0275 mL 0.1376 mL 0.2751 mL 0.6878 mL
100 mM 0.0220 mL 0.1100 mL 0.2201 mL 0.5502 mL
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HNMPA-(AM)3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HNMPA-(AM)3120944-03-8Insulin ReceptorERK phosphorylationinsulin receptor substrate-1IRS-1Ser794Inhibitorinhibitorinhibit

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