Art. -Nr.: HY-149992

MyD88-IN-1

5 Cited Publications

Kundenbewertung

Based on 5 publication(s) in Google Scholar

MyD88-IN-1 (Compound c17) is an orally active MyD88 inhibitor. MyD88-IN-1 inhibits the interaction of TLR4 and MyD88 and suppressed the NF-κB pathway. MyD88-IN-1 can be used in research of cancer and inflammatory.

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Reinheit: 98.38%
CAS. Nr.: 2911609-80-6
Formel: C₂₃H₂₄N₆O₇S
Molecular Weight:528.54

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MyD88-IN-1 Chemical Structure

CAS. Nr.: 2911609-80-6

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	2.17 μM Compound: c17	Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced IL-6 production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis	[PMID: 37130331]
J774.A1	IC₅₀	8.17 μM Compound: c17	Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis Anti-inflammatory activity in mouse J774.A1 cells assessed as inhibition of LPS-induced TNF-alpha production pre-stimulated with LPS for 24 hrs followed by compound addition and measured after 0.5 hrs by ELISA analysis	[PMID: 37130331]

In Vitro

MyD88-IN-1 (10 μM, 24 h) exhibits significant anti-inflammatory effects in LPS (HY-D1056)-induced J774A.1 macrophages^[1].
MyD88-IN-1 (40 or 80 μM, 2 h) restores IκB-α expression and inhibits p65 phosphorylation and nuclear translocation, indicating that it exerts anti-inflammatory effects by suppressing the NF-κB signaling pathway^[1].
MyD88-IN-1 (40 or 80 μM, 2 h) exerts its anti-inflammatory activity in J774A.1 macrophages by inhibiting TLR4-MyD88 interaction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

J774A.1 macrophages (mouse-derived)
Concentration:

40 μM, 80 μM
Incubation Time:

2 h
Result:

Restored IκB-α expression, inhibited p65 phosphorylation and nuclear translocation.

In Vivo

MyD88-IN-1 (20 mg/kg, p.o., single dose) exhibits significant anti-inflammatory effects and alleviates lung tissue injury in the LPS (HY-D1056)-induced ALI mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

LPS (HY-D1056)-induced acute lung injury (ALI) in C57BL/6L mice^[1]
Dosage:

20 mg/kg
Administration:

Oral gavage (p.o.), single dose, Administered 30 minutes before LPS induction
Result:

Significantly reduced TNF-α and IL-6 levels in BALF and serum;
Decreased wet/dry lung ratio and total protein concentration;
Alleviated lung tissue histopathological changes.

Chemical Information

CAS. Nr. 2911609-80-6
Appearance Solid
Molecular Weight 528.54
Formel C₂₃H₂₄N₆O₇S
Color Yellow to orange
SMILES

O=[N+](C1=CC=CC(CN2CCN(CC2)C3=CC=C(S(=O)(NC4=CN=C(C=C4)OC)=O)C=C3[N+]([O-])=O)=C1)[O-]
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (5)

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Journal Impact Factor

J Extracell Vesicles

Extracellular Vesicles Derived From Streptococcus anginosus Aggravate Lupus Nephritis by Triggering TLR2-MyD88-NF-κB Signalling in NK Cells. [Abstract]

2025 Jul;14(7):e70134. PMID: 40673809
Adv Sci (Weinh)

Activated Platelet-Released Heat Shock Protein 90α Triggers Autophagy-Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis. [Abstract]

2026 May;13(25):e15933. PMID: 41732887
Adv Sci (Weinh)

VDLIN: A Deep Learning-Based Platform for Methylcobalamin-Inspired Immunomodulatory Compound Screening. [Abstract]

2025 Oct 27:e13775. PMID: 41144841
Phytomedicine

Shen-Shuai-Ⅱ Recipe ameliorates chronic kidney disease-induced myocardial injury via inhibition of the IL-18/IL-18R1/MyD88 pathway. [Abstract]

2026 Mar:152:157877. PMID: 41621346
Res Sq

2025 Jul 17.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (189.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8920 mL

9.4600 mL

18.9200 mL

5 mM

0.3784 mL

1.8920 mL

3.7840 mL

10 mM

0.1892 mL

0.9460 mL

1.8920 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen P, et, al. Design, Synthesis, and Bioevaluation of Novel MyD88 Inhibitor c17 against Acute Lung Injury Derived from the Virtual Screen. J Med Chem. 2023 May 25;66(10):6938-6958. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8920 mL	9.4600 mL	18.9200 mL	47.3001 mL
	5 mM	0.3784 mL	1.8920 mL	3.7840 mL	9.4600 mL
	10 mM	0.1892 mL	0.9460 mL	1.8920 mL	4.7300 mL
	15 mM	0.1261 mL	0.6307 mL	1.2613 mL	3.1533 mL
	20 mM	0.0946 mL	0.4730 mL	0.9460 mL	2.3650 mL
	25 mM	0.0757 mL	0.3784 mL	0.7568 mL	1.8920 mL
	30 mM	0.0631 mL	0.3153 mL	0.6307 mL	1.5767 mL
	40 mM	0.0473 mL	0.2365 mL	0.4730 mL	1.1825 mL
	50 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.9460 mL
	60 mM	0.0315 mL	0.1577 mL	0.3153 mL	0.7883 mL
	80 mM	0.0237 mL	0.1183 mL	0.2365 mL	0.5913 mL
	100 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.4730 mL

Keywords

MyD88-IN-1

5 Cited Publications

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MyD88-IN-1

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Anti-Obesity Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MyD88-IN-1

Biologische Aktivität

Chemical Information

Publications (5)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MyD88-IN-1

Bioactive Compound Library Max

Bioactive Compound Library

Immunology/Inflammation Compound Library

NF-κB Signaling Compound Library

Anti-Cancer Compound Library

Orally Active Compound Library

Anti-Obesity Compound Library

MCE Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MyD88-IN-1

Biologische Aktivität

Chemical Information

Publications (5)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MyD88-IN-1 Related Classifications

HY-149992 Related Classifications