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Art. -Nr.: HY-121492

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NSC 45576

NSC 45576 is a selective inhibitor of XendoU endoribonuclease and an inhibitor of CREB-CRE interaction, with an IC₅₀ value of 29 μM against Xenopus laevis XendoU. NSC 45576 binds to the active sites of XendoU and PP11, and inhibits CREB-CRE interaction. NSC 45576 can be used in cancer-related research such as breast cancer and gastric cancer.

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CAS. Nr.: 1414586-62-1
Formel: C₂₀H₁₄N₂O₄S
Molecular Weight:378.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC 45576 Chemical Structure

CAS. Nr.: 1414586-62-1

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

NSC 45576 (compound 3) potently inhibits the endoribonucleolytic activity of recombinant Xenopus laevis His-XendoU with an IC₅₀ of 29 μM, and fully blocks activity at 200 μM^[1].
NSC 45576 inhibits the endoribonucleolytic activity of recombinant human His-PP11 in a dose-dependent manner^[1].
NSC 45576 acts as a non-specific inhibitor of CREB-CRE interaction in a high-throughput screening assay^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1414586-62-1
Molecular Weight 378.40
Formel C₂₀H₁₄N₂O₄S
SMILES

O=C1C=CC=2C=CC=CC2C1=NNC3=CC=CC4=CC(=CC=C43)S(=O)(=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Ragno R, et al. Identification of small-molecule inhibitors of the XendoU endoribonucleases family. ChemMedChem. 2011 Oct 04;6(10):1797-805. [Content Brief]

[2]. Xiao X, et al. Targeting CREB for cancer therapy: friend or foe. Current cancer drug targets. 2010 Jun;10(4):384-91. [Content Brief]

[3]. Jiang M, et al. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. Journal of cellular and molecular medicine. 2019 Feb;23(2):1224-1234. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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