1414586-62-1
Chemical Structure
NSC 45576
- CAS No.: 1414586-62-1
- Formula:C20H14N2O4S
- Molecular Weight:378.40
IUPAC Name: (Z)-5-(2-(2-oxonaphthalen-1(2H)-ylidene)hydrazinyl)naphthalene-2-sulfonic acid
InChIKey: SNLUQQRVRKIXKE-XDOYNYLZSA-N
SMILES: O=C1C=CC=2C=CC=CC2C1=NNC3=CC=CC4=CC(=CC=C43)S(=O)(=O)O
Biological Activity: NSC 45576 is a selective inhibitor of XendoU endoribonuclease and an inhibitor of CREB-CRE interaction, with an IC50 value of 29 μM against Xenopus laevis XendoU. NSC 45576 binds to the active sites of XendoU and PP11, and inhibits CREB-CRE interaction. NSC 45576 can be used in cancer-related research such as breast cancer and gastric cancer[1].
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NSC 45576 | NSC 45576 is a selective inhibitor of XendoU endoribonuclease and an inhibitor of CREB-CRE interaction, with an IC50 value of 29 μM against Xenopus laevis XendoU. NSC 45576 binds to the active sites of XendoU and PP11, and inhibits CREB-CRE interaction. NSC 45576 can be used in cancer-related research such as breast cancer and gastric cancer. | |||||||||||||||||||||
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Keywords
