NSC 45576
NSC 45576 is a selective inhibitor of XendoU endoribonuclease and an inhibitor of CREB-CRE interaction, with an IC50 value of 29 μM against Xenopus laevis XendoU. NSC 45576 binds to the active sites of XendoU and PP11, and inhibits CREB-CRE interaction. NSC 45576 can be used in cancer-related research such as breast cancer and gastric cancer.
For research use only. We do not sell to patients.
- CAS No.: 1414586-62-1
- Formula: C20H14N2O4S
- Molecular Weight:378.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
NSC 45576 (compound 3) potently inhibits the endoribonucleolytic activity of recombinant Xenopus laevis His-XendoU with an IC50 of 29 μM, and fully blocks activity at 200 μM[1].
NSC 45576 inhibits the endoribonucleolytic activity of recombinant human His-PP11 in a dose-dependent manner[1].
NSC 45576 acts as a non-specific inhibitor of CREB-CRE interaction in a high-throughput screening assay[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1414586-62-1
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Molecular Weight 378.40
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Formula C20H14N2O4S
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SMILES
O=C1C=CC=2C=CC=CC2C1=NNC3=CC=CC4=CC(=CC=C43)S(=O)(=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Ragno R, et al. Identification of small-molecule inhibitors of the XendoU endoribonucleases family. ChemMedChem. 2011 Oct 04;6(10):1797-805. [Content Brief]
[2]. Xiao X, et al. Targeting CREB for cancer therapy: friend or foe. Current cancer drug targets. 2010 Jun;10(4):384-91. [Content Brief]
[3]. Jiang M, et al. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. Journal of cellular and molecular medicine. 2019 Feb;23(2):1224-1234. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NSC 45576 Related Classifications
HY-121492 Related Classifications
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