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Art. -Nr.: HY-184696

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Pomalidomide-C16-azide

Pomalidomide-C16-azide is a PROTAC E3 ligase ligand-linker conjugate that can be used in studies related to PROTAC synthesis, such as serving as the E3+linker structure of PROTAC CDK9 degrader-13 (HY-184693).

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Formel: C₂₉H₄₂N₆O₄
Molecular Weight:538.68

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pomalidomide-C16-azide Chemical Structure

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
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Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen :

In Vitro

Pomalidomide-C16-azide (compound 9f) serves as the E3 ligase ligand-linker conjugate of PROTAC CDK9 degrader-13 (HY-184693). PROTAC CDK9 degrader-13 is a selective CDK9 PROTAC degrader. It downregulates the anti-apoptotic protein Mcl-1, activates the Caspase-3 pathway, and induces apoptosis in acute myeloid leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 538.68
Formel C₂₉H₄₂N₆O₄
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCCCCCCCCCCCN=[N+]=[N-])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li Q, et al. Discovery of selective CDK9 degraders with anti-AML activity using PROTAC technology. Bioorganic chemistry. 2026 Jun 12;180:110091. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- In Vitro
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Pomalidomide-C16-azide

Alle E3 Ligase Ligand-Linker Conjugates Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Pomalidomide-C16-azide Related Classifications

HY-184696 Related Classifications