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UNC50 - unc-50 inner nuclear membrane RNA binding protein Gene

Also Known as URP; GMH1; UNCL; HSD23; PDLs22

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25972

About UNC50

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:98,608,589-98,618,515 (from NCBI)

This gene has 6 transcripts (splice variants) and 206 orthologues. Ubiquitous expression in thyroid (RPKM 28.7), testis (RPKM 24.9) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Predicted to be located in Golgi apparatus and nuclear inner membrane. Predicted to be integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]

UNC50 Products (3)

mRNA	Protein	Name
NM_001330353.2	NP_001317282.1	protein unc-50 homolog isoform 2
NM_001330354.2	NP_001317283.1	protein unc-50 homolog isoform 1
NM_014044.7	NP_054763.2	protein unc-50 homolog isoform 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC50 Protein Structure

UNC-50

0
100
200
259 a.a.

Protein Preferred Names	Protein Names
protein unc-50 homolog	geal-6 membrane-associated high-copy suppressor 1

UNC50 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UNC50	Q53HI1	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	UNC50	Q53HI1	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Array	32296183
Intra	UNC50	Q53HI1	HSD17B11	Homo sapiens	Q8NBQ5	Validated Y2H	32296183
Intra	UNC50	Q53HI1	HSD17B11	Homo sapiens	Q8NBQ5	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	TMED8	Homo sapiens	Q6PL24	Validated Y2H	32296183
Intra	UNC50	Q53HI1	TMED8	Homo sapiens	Q6PL24	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	TMED8	Homo sapiens	Q6PL24	Y2H Array	32296183
Intra	UNC50	Q53HI1	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	UNC50	Q53HI1	GPX8	Homo sapiens	Q8TED1	Validated Y2H	32296183
Intra	UNC50	Q53HI1	FITM2	Homo sapiens	Q8N6M3	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	FITM2	Homo sapiens	Q8N6M3	Y2H Array	32296183
Intra	UNC50	Q53HI1	FITM2	Homo sapiens	Q8N6M3	Validated Y2H	32296183
Intra	UNC50	Q53HI1	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	UNC50	Q53HI1	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	UNC50	Q53HI1	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	UNC50	Q53HI1	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	UNC50	Q53HI1	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	UNC50	Q53HI1	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	UNC50	Q53HI1	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	UNC50	Q53HI1	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	CLRN1	Homo sapiens	P58418	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	CLRN1	Homo sapiens	P58418	Y2H Array	32296183
Intra	UNC50	Q53HI1	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	UNC50	Q53HI1	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	UNC50	Q53HI1	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	HSD17B13	Homo sapiens	Q7Z5P4	Validated Y2H	32296183
Intra	UNC50	Q53HI1	HSD17B13	Homo sapiens	Q7Z5P4	Y2H Array	32296183
Intra	UNC50	Q53HI1	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	UNC50	Q53HI1	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	UNC50	Q53HI1	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	UNC50	Q53HI1	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	ELOVL4	Homo sapiens	Q9GZR5	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	ELOVL4	Homo sapiens	Q9GZR5	Validated Y2H	32296183
Intra	UNC50	Q53HI1	ELOVL4	Homo sapiens	Q9GZR5	Y2H Array	32296183
Intra	UNC50	Q53HI1	FFAR2	Homo sapiens	O15552	Y2H Array	32296183
Intra	UNC50	Q53HI1	FFAR2	Homo sapiens	O15552	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	CLEC10A	Homo sapiens	Q8IUN9	Y2H Array	32296183
Intra	UNC50	Q53HI1	CLEC10A	Homo sapiens	Q8IUN9	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	CLEC10A	Homo sapiens	Q8IUN9	Validated Y2H	32296183
Intra	UNC50	Q53HI1	MFSD14B	Homo sapiens	Q5SR56	Y2H Array	32296183
Intra	UNC50	Q53HI1	MFSD14B	Homo sapiens	Q5SR56	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	MFSD14B	Homo sapiens	Q5SR56	Validated Y2H	32296183
Intra	UNC50	Q53HI1	IFNGR2	Homo sapiens	P38484	Y2H Array	32296183
Intra	UNC50	Q53HI1	IFNGR2	Homo sapiens	P38484	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	UNC50	Q53HI1	DARS2	Homo sapiens	Q6PI48	Validated Y2H	32296183
Intra	UNC50	Q53HI1	DARS2	Homo sapiens	Q6PI48	Y2H Array	32296183
Intra	UNC50	Q53HI1	DARS2	Homo sapiens	Q6PI48	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	SAR1A	Homo sapiens	Q9NR31	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	SAR1A	Homo sapiens	Q9NR31	Validated Y2H	32296183
Intra	UNC50	Q53HI1	SAR1A	Homo sapiens	Q9NR31	Y2H Array	32296183
Intra	UNC50	Q53HI1	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	UNC50	Q53HI1	MTIF3	Homo sapiens	Q9H2K0	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	MTIF3	Homo sapiens	Q9H2K0	Validated Y2H	32296183
Intra	UNC50	Q53HI1	MTIF3	Homo sapiens	Q9H2K0	Y2H Array	32296183
Intra	UNC50	Q53HI1	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	UNC50	Q53HI1	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	UNC50	Q53HI1	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	UNC50	Q53HI1	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	UNC50	Q53HI1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	UNC50	Q53HI1	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	UNC50	Q53HI1	TMEM234	Homo sapiens	Q8WY98	Y2H Prey Pooling	32296183
Intra	UNC50	Q53HI1	TMEM234	Homo sapiens	Q8WY98	Y2H Array	32296183
Intra	UNC50	Q53HI1	TMEM234	Homo sapiens	Q8WY98	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Immunodeficiency 13	Idiopathic Cd4 Lymphopenia IMD13 Icl Immunodeficiency, Type 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15470	UNC50 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UNC50	MGD	MGI:1914637
Felis catus	UNC50	VGNC	VGNC:66827
Macaca mulatta	UNC50	VGNC	VGNC:79004
Canis familiaris	UNC50	VGNC	VGNC:108222
Bos taurus	UNC50	VGNC	VGNC:36669
Rattus norvegicus	UNC50	RGD	RGD:621749
Others	UNC50	NCBI