KR-27425
AChE activator 1 (compound 13) is a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase(AChE).
For research use only. We do not sell to patients.
- CAS No.: 3047755-18-7
- Formula: C10H21N3O2
- Molecular Weight:215.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO-K1 | CC50 |
>100 μM
Compound: 13; KR-27425
|
Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against CHO-K1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 37838342] |
| HFL1 | CC50 |
>100 μM
Compound: 13; KR-27425
|
Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human HFL1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 37838342] |
| L929 | CC50 |
>100 μM
Compound: 13; KR-27425
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Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse L929 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 37838342] |
| NIH3T3 | CC50 |
>100 μM
Compound: 13; KR-27425
|
Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against mouse NIH3T3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
|
[PMID: 37838342] |
| Vero | CC50 |
>100 μM
Compound: 13; KR-27425
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 37838342] |
Chemical Information
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CAS No. 3047755-18-7
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Molecular Weight 215.29
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Formula C10H21N3O2
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SMILES
CC(CCCNCCNC(/C=N/O)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Vishakantegowda AG, et al. Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129504. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KR-27425 Related Classifications
HY-156399 Related Classifications
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