2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Atpenin A5

Atpenin A5 

Cat. No.: HY-126653 Purity: 99.42%
COA Handling Instructions

Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent.

For research use only. We do not sell to patients.

Atpenin A5 Chemical Structure

Atpenin A5 Chemical Structure

CAS No. : 119509-24-9

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1 mg USD 310 In-stock
Estimated Time of Arrival: December 31
5 mg USD 630 In-stock
Estimated Time of Arrival: December 31
10 mg USD 980 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1960 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Atpenin A5 is a potent and highly specific complex II inhibitor (IC50 ~10 nM), and is an effective mKATP channel agonist and cardioprotective agent[1].

In Vitro

Atpenin A5 shows the inhibition profile for submitochondrial particles (SMPs), mitochondria, and cardiomyocytes, with IC50 values of 8.3, 9.3, and 8.5 nM, respectively. Atpenin A5 (AA5) is a potent and specific complex II inhibitor. Atpenin A5 (1 nM) also activates the mKATP channel and protects against simulated ischemia-reperfusion (IR) injury in isolated cardiomyocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Atpenin A5 is a potent inhibitor of succinate dehydrogenase (SDH). Succinate dehydrogenase inhibition by Atpenin A5 promotes cardiomyocyte mitosis and regeneration in the postnatal heart after myocardial infarction (MI). Atpenin A5-injected mice demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Neonatal mice[2]
Dosage: 100 μg/kg
Administration: Injected daily
Result: Demonstrated myocardial thickness at the infarct zone and a significant reduction in scar size compared with controls.
Molecular Weight

366.24

Appearance

Solid

Formula

C15H21Cl2NO5
CAS No.
SMILES

O=C1C(C([[email protected]@H](C)C[[email protected]](C)[[email protected]@H](Cl)CCl)=O)=C(O)C(OC)=C(OC)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (273.04 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7304 mL 13.6523 mL 27.3045 mL
5 mM 0.5461 mL 2.7304 mL 5.4609 mL
10 mM 0.2730 mL 1.3652 mL 2.7304 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.83 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.42%

COA (247 KB) HNMR (253 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Atpenin A5119509-24-9Atpenin A 5Atpenin A-5Potassium ChannelKcsAcomplex IImKATPchannelcardioprotectivepreconditioningischemiareperfusionmitochondrialATPsensitivepotassiumInhibitorinhibitorinhibit

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