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Cat. No.: HY-133703

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AZD1775-C3-NH2

AZD1775-C3-NH2 is a Target Protein Ligand-Linker Conjugate that contains a target protein ligand and a PROTAC linker, and can recruit E3 ligases. AZD1775-C3-NH2 can be used for the synthesis of Pomalidomide-C3-adavosertib (HY-133618).

For research use only. We do not sell to patients.

CAS No.: 2101954-45-2
Formula: C₂₉H₃₇N₉O₂
Molecular Weight:543.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AZD1775-C3-NH2 Chemical Structure

CAS No.: 2101954-45-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Wee1 Isoforms :

PKMYT1

Chemical Information

CAS No. 2101954-45-2
Molecular Weight 543.66
Formula C₂₉H₃₇N₉O₂
SMILES

O=C1N(CC=C)N(C2=NC(C(C)(O)C)=CC=C2)C3=NC(NC4=CC=C(N5CCN(CCCN)CC5)C=C4)=NC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wright G, et al. Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity. ACS chemical biology. 2017 Jul 21;12(7):1883-1892. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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AZD1775-C3-NH2

All Wee1 Isoforms